DUFMech

All families / PF04535

PF04535: CASP_dom

Casparian strip membrane protein domain

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF04535: Casparian strip membrane protein domain
IPR006702: integrated entry for Casparian strip membrane protein domain

Source description

This domain is found mainly in plant proteins known as Casparian strip membrane proteins (CASPs) and CASP-like proteins (CASPLs). CASPs are four-membrane-span proteins that mediate the deposition of Casparian strips in the endodermis by recruiting the lignin polymerization machinery. Interestingly, the CASP first extracellular loop was found conserved in euphyllophytes but absent in plants lacking Casparian strips [InterPro reference PUB00088572,InterPro reference PUB00072979].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

12 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
Q3ECT8CASP-like protein 5C3
Arabidopsis thaliana		152 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q6NPF8CASP-like protein 5A1
Arabidopsis thaliana		180 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q84UT5CASP-like protein BLE3
Oryza sativa subsp. japonica		162 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q8L8Z1CASP-like protein 1E1
Arabidopsis thaliana		190 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9CAX3Casparian strip membrane protein 2
Arabidopsis thaliana		204 aa; version 1
UniProt 2026_03		PTM REGISTRY MIRROR
3 sibling references
Q9FE29CASP-like protein 1D1
Arabidopsis thaliana		193 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9FFZ7Casparian strip membrane protein 4
Arabidopsis thaliana		202 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q9LXF3Casparian strip membrane protein 5
Arabidopsis thaliana		187 aa; version 1
UniProt 2026_03		UNIPROT FETCH
3 sibling references
Q9LZM5CASP-like protein 5B1
Arabidopsis thaliana		152 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q9SIH4Casparian strip membrane protein 1
Arabidopsis thaliana		206 aa; version 1
UniProt 2026_03		UNIPROT FETCH
3 sibling references

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
17,754
matches
18,024
proteomes
388
taxa
1,108
structures
0
alphafold models
14,486
domain architectures
223

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF04535.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.