DUFMech

All families / PF04574

PF04574: DUF592

Protein of unknown function (DUF592)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF04574: Protein of unknown function (DUF592)
IPR007654: integrated entry for Protein of unknown function (DUF592)

Source description

This region is found in some SIR2 family proteins (PF02146 (Pfam entry)).

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

3 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O94640NAD-dependent histone deacetylase sir2
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
475 aa; version 2
UniProt 2026_03
UNIPROT FETCH
1 sibling references
P06700NAD-dependent histone deacetylase SIR2
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
562 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
19 sibling references
P53685NAD-dependent protein deacetylase HST1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
503 aa; version 1
UniProt 2026_03
UNIPROT FETCH
11 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
354
matches
393
proteomes
302
taxa
760
structures
2
alphafold models
299
domain architectures
8

Classification basis

short name matches duf; name says unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF592 (PF04574)ProteinTraitsMechchromatin silencing complexP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechRENT complexP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechSet3 complexP53685
NAD-dependent protein deacetylase HST1
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechDNA replication origin bindingP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechhistone H3K14 deacetylase activity, NAD-dependentP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechhistone H3K14 deacetylase activity, NAD-dependentP53685
NAD-dependent protein deacetylase HST1
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechhistone H3K9 deacetylase activity, NAD-dependentP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechhistone H3K9 deacetylase activity, NAD-dependentP53685
NAD-dependent protein deacetylase HST1
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechhistone H4K16 deacetylase activity, NAD-dependentP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechhistone H4K16 deacetylase activity, NAD-dependentP53685
NAD-dependent protein deacetylase HST1
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechestablishment of protein-containing complex localization to telomereP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechnegative regulation of DNA amplificationP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechnegative regulation of DNA recombinationP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechnegative regulation of DNA replicationP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechnegative regulation of meiotic nuclear divisionP53685
NAD-dependent protein deacetylase HST1
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechnegative regulation of mitotic recombinationP53685
NAD-dependent protein deacetylase HST1
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechrDNA heterochromatin formationP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechregulation of DNA stabilityP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechregulation of mating type switchingP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechregulation of sporulationP53685
NAD-dependent protein deacetylase HST1
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechregulation of thiamine biosynthetic processP53685
NAD-dependent protein deacetylase HST1
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechNAD-dependent histone deacetylase Sir2, N-terminalP06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechNAD-dependent histone deacetylase Sir2, N-terminalP53685
NAD-dependent protein deacetylase HST1
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechNAD-dependent histone deacetylase Sir2, N-terminal
trait identifier
DUF592 (PF04574)ProteinTraitsMechProtein of unknown function (DUF592)O94640
NAD-dependent histone deacetylase sir2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechProtein of unknown function (DUF592)P06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechProtein of unknown function (DUF592)P53685
NAD-dependent protein deacetylase HST1
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechProtein of unknown function (DUF592)
trait identifier
DUF592 (PF04574)ProteinTraitsMechCATH homologous superfamily 1.20.120.1710P06700
NAD-dependent histone deacetylase SIR2
canonical example family classification
DUF592 (PF04574)ProteinTraitsMechCATH homologous superfamily 1.20.120.1710P53685
NAD-dependent protein deacetylase HST1
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF04574.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.