All families / PF04574
PF04574: DUF592
Protein of unknown function (DUF592)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF04574: Protein of unknown function (DUF592)
IPR007654: integrated entry for Protein of unknown function (DUF592)
Source description
This region is found in some SIR2 family proteins (PF02146 (Pfam entry)).
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 354
- matches
- 393
- proteomes
- 302
- taxa
- 760
- structures
- 2
- alphafold models
- 299
- domain architectures
- 8
Classification basis
short name matches duf; name says unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF592 (PF04574) | ProteinTraitsMech | chromatin silencing complex | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | RENT complex | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | Set3 complex | P53685 NAD-dependent protein deacetylase HST1 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | DNA replication origin binding | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | histone H3K14 deacetylase activity, NAD-dependent | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | histone H3K14 deacetylase activity, NAD-dependent | P53685 NAD-dependent protein deacetylase HST1 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | histone H3K9 deacetylase activity, NAD-dependent | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | histone H3K9 deacetylase activity, NAD-dependent | P53685 NAD-dependent protein deacetylase HST1 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | histone H4K16 deacetylase activity, NAD-dependent | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | histone H4K16 deacetylase activity, NAD-dependent | P53685 NAD-dependent protein deacetylase HST1 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | establishment of protein-containing complex localization to telomere | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | negative regulation of DNA amplification | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | negative regulation of DNA recombination | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | negative regulation of DNA replication | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | negative regulation of meiotic nuclear division | P53685 NAD-dependent protein deacetylase HST1 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | negative regulation of mitotic recombination | P53685 NAD-dependent protein deacetylase HST1 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | rDNA heterochromatin formation | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | regulation of DNA stability | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | regulation of mating type switching | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | regulation of sporulation | P53685 NAD-dependent protein deacetylase HST1 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | regulation of thiamine biosynthetic process | P53685 NAD-dependent protein deacetylase HST1 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | NAD-dependent histone deacetylase Sir2, N-terminal | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | NAD-dependent histone deacetylase Sir2, N-terminal | P53685 NAD-dependent protein deacetylase HST1 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | NAD-dependent histone deacetylase Sir2, N-terminal | trait identifier | |
| DUF592 (PF04574) | ProteinTraitsMech | Protein of unknown function (DUF592) | O94640 NAD-dependent histone deacetylase sir2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | Protein of unknown function (DUF592) | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | Protein of unknown function (DUF592) | P53685 NAD-dependent protein deacetylase HST1 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | Protein of unknown function (DUF592) | trait identifier | |
| DUF592 (PF04574) | ProteinTraitsMech | CATH homologous superfamily 1.20.120.1710 | P06700 NAD-dependent histone deacetylase SIR2 | canonical example family classification |
| DUF592 (PF04574) | ProteinTraitsMech | CATH homologous superfamily 1.20.120.1710 | P53685 NAD-dependent protein deacetylase HST1 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.