All families / PF04727
PF04727: ELMO_CED12
ELMO/CED-12 family
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF04727: ELMO/CED-12 family
IPR006816: integrated entry for ELMO/CED-12 family
Source description
This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells [InterPro reference PUB00019508]. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment.
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
14 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q09292 | ELMO domain-containing protein elmd-1 Caenorhabditis elegans | 322 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q3V1U8 | ELMO domain-containing protein 1 Mus musculus | 326 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q8BGF6 | ELMO domain-containing protein 2 Mus musculus | 293 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q8BHL5 | Engulfment and cell motility protein 2 Mus musculus | 732 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q8BPU7 | Engulfment and cell motility protein 1 Mus musculus | 727 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q8BYZ7 | Engulfment and cell motility protein 3 Mus musculus | 720 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q8IZ81 | ELMO domain-containing protein 2 Homo sapiens | 293 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q8N336 | ELMO domain-containing protein 1 Homo sapiens | 334 aa; version 3 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q8STE5 | Cell death abnormality protein 12 Caenorhabditis elegans | 731 aa; version 1 UniProt 2026_03 | UNIPROT FETCH11 sibling references
|
| Q91YP6 | ELMO domain-containing protein 3 Mus musculus | 381 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
First 10 shown; the FASTA and family JSON contain all examples.
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 14,425
- matches
- 14,729
- proteomes
- 3,212
- taxa
- 8,666
- structures
- 15
- alphafold models
- 12,473
- domain architectures
- 226
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.