All families / PF05057
PF05057: DUF676
Putative serine esterase (DUF676)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF05057: Putative serine esterase (DUF676)
IPR007751: integrated entry for Putative serine esterase (DUF676)
Source description
This domain, whose function is unknown, is found within a group of putative lipases. Proteins containing this domain include YOR059C (Lpl1) from budding yeasts. Lpl1 has been identified as a phospholipase B [InterPro reference PUB00073522]. They contain an alpha/beta hydrolase fold.
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
8 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| P53118 | Putative lipase ROG1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 685 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q04093 | Putative lipase YDR444W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 687 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q08448 | Lipid droplet phospholipase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 450 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q12103 | Putative lipase YDL109C Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 647 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q49AJ0 | Protein FAM135B Homo sapiens | 1406 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q6NS59 | Protein FAM135A Mus musculus | 1506 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9DAI6 | Protein FAM135B Mus musculus | 1403 aa; version 3 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q9P2D6 | Protein FAM135A Homo sapiens | 1515 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 15,503
- matches
- 16,829
- proteomes
- 4,005
- taxa
- 10,132
- structures
- 0
- alphafold models
- 10,211
- domain architectures
- 547
Classification basis
short name matches duf; description says unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF676 (PF05057) | ProteinTraitsMech | phosphatidylethanolamine lysophospholipase A1 activity | Q08448 Lipid droplet phospholipase 1 | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Domain of unknown function DUF676, lipase-like | P53118 Putative lipase ROG1 | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Domain of unknown function DUF676, lipase-like | Q04093 Putative lipase YDR444W | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Domain of unknown function DUF676, lipase-like | Q08448 Lipid droplet phospholipase 1 | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Domain of unknown function DUF676, lipase-like | Q12103 Putative lipase YDL109C | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Domain of unknown function DUF676, lipase-like | Q49AJ0 Protein FAM135B | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Domain of unknown function DUF676, lipase-like | Q6NS59 Protein FAM135A | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Domain of unknown function DUF676, lipase-like | Q9DAI6 Protein FAM135B | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Domain of unknown function DUF676, lipase-like | Q9P2D6 Protein FAM135A | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Domain of unknown function DUF676, lipase-like | trait identifier | |
| DUF676 (PF05057) | ProteinTraitsMech | Protein FAM135 | Q49AJ0 Protein FAM135B | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Protein FAM135 | Q9DAI6 Protein FAM135B | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Protein FAM135 | Q9P2D6 Protein FAM135A | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Putative serine esterase (DUF676) | Q08448 Lipid droplet phospholipase 1 | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Putative serine esterase (DUF676) | Q49AJ0 Protein FAM135B | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Putative serine esterase (DUF676) | Q9P2D6 Protein FAM135A | canonical example family classification |
| DUF676 (PF05057) | ProteinTraitsMech | Putative serine esterase (DUF676) | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.