DUFMech

All families / PF05057

PF05057: DUF676

Putative serine esterase (DUF676)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF05057: Putative serine esterase (DUF676)
IPR007751: integrated entry for Putative serine esterase (DUF676)

Source description

This domain, whose function is unknown, is found within a group of putative lipases. Proteins containing this domain include YOR059C (Lpl1) from budding yeasts. Lpl1 has been identified as a phospholipase B [InterPro reference PUB00073522]. They contain an alpha/beta hydrolase fold.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

8 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
P53118Putative lipase ROG1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
685 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q04093Putative lipase YDR444W
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
687 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q08448Lipid droplet phospholipase 1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
450 aa; version 1
UniProt 2026_03
UNIPROT FETCH
3 sibling references
Q12103Putative lipase YDL109C
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
647 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q49AJ0Protein FAM135B
Homo sapiens
1406 aa; version 2
UniProt 2026_03
PTM REGISTRY MIRROR
4 sibling references
Q6NS59Protein FAM135A
Mus musculus
1506 aa; version 2
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q9DAI6Protein FAM135B
Mus musculus
1403 aa; version 3
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q9P2D6Protein FAM135A
Homo sapiens
1515 aa; version 2
UniProt 2026_03
UNIPROT FETCH
3 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
15,503
matches
16,829
proteomes
4,005
taxa
10,132
structures
0
alphafold models
10,211
domain architectures
547

Classification basis

short name matches duf; description says unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF676 (PF05057)ProteinTraitsMechphosphatidylethanolamine lysophospholipase A1 activityQ08448
Lipid droplet phospholipase 1
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechDomain of unknown function DUF676, lipase-likeP53118
Putative lipase ROG1
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechDomain of unknown function DUF676, lipase-likeQ04093
Putative lipase YDR444W
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechDomain of unknown function DUF676, lipase-likeQ08448
Lipid droplet phospholipase 1
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechDomain of unknown function DUF676, lipase-likeQ12103
Putative lipase YDL109C
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechDomain of unknown function DUF676, lipase-likeQ49AJ0
Protein FAM135B
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechDomain of unknown function DUF676, lipase-likeQ6NS59
Protein FAM135A
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechDomain of unknown function DUF676, lipase-likeQ9DAI6
Protein FAM135B
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechDomain of unknown function DUF676, lipase-likeQ9P2D6
Protein FAM135A
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechDomain of unknown function DUF676, lipase-like
trait identifier
DUF676 (PF05057)ProteinTraitsMechProtein FAM135Q49AJ0
Protein FAM135B
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechProtein FAM135Q9DAI6
Protein FAM135B
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechProtein FAM135Q9P2D6
Protein FAM135A
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechPutative serine esterase (DUF676)Q08448
Lipid droplet phospholipase 1
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechPutative serine esterase (DUF676)Q49AJ0
Protein FAM135B
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechPutative serine esterase (DUF676)Q9P2D6
Protein FAM135A
canonical example family classification
DUF676 (PF05057)ProteinTraitsMechPutative serine esterase (DUF676)
trait identifier

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF05057.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.