All families / PF05598
PF05598: DUF772
Transposase domain (DUF772)
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF05598: Transposase domain (DUF772)
IPR008490: integrated entry for Transposase domain (DUF772)
Source description
This presumed domain is found at the N-terminus of many proteins found in transposons.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
8 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A0A385XJE6 | Transposase InsH for insertion sequence element IS5U Escherichia coli (strain K12) | 326 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| P0CE49 | Transposase InsH for insertion sequence element IS5A Escherichia coli (strain K12) | 326 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| P0CE50 | Transposase InsH for insertion sequence element IS5B Escherichia coli (strain K12) | 326 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| P0CE51 | Transposase InsH for insertion sequence element IS5D Escherichia coli (strain K12) | 326 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| P0CE52 | Transposase InsH for insertion sequence element IS5F Escherichia coli (strain K12) | 326 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| P0CE53 | Transposase InsH for insertion sequence element IS5H Escherichia coli (strain K12) | 326 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| P0CE54 | Transposase InsH for insertion sequence element IS5I Escherichia coli (strain K12) | 326 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| P76071 | Transposase InsH for insertion sequence element IS5Y Escherichia coli (strain K12) | 326 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 17,572
- matches
- 17,574
- proteomes
- 6,555
- taxa
- 10,733
- structures
- 0
- alphafold models
- 11,560
- domain architectures
- 78
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF772 (PF05598) | ProteinTraitsMech | transposase activity | A0A385XJE6 Transposase InsH for insertion sequence element IS5U | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | transposase activity | P0CE49 Transposase InsH for insertion sequence element IS5A | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | transposase activity | P0CE50 Transposase InsH for insertion sequence element IS5B | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | transposase activity | P0CE51 Transposase InsH for insertion sequence element IS5D | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | transposase activity | P0CE52 Transposase InsH for insertion sequence element IS5F | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | transposase activity | P76071 Transposase InsH for insertion sequence element IS5Y | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | DNA transposition | P76071 Transposase InsH for insertion sequence element IS5Y | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | IS5 family transposase | A0A385XJE6 Transposase InsH for insertion sequence element IS5U | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | IS5 family transposase | P0CE49 Transposase InsH for insertion sequence element IS5A | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | IS5 family transposase | P0CE50 Transposase InsH for insertion sequence element IS5B | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | IS5 family transposase | P0CE51 Transposase InsH for insertion sequence element IS5D | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | IS5 family transposase | P0CE52 Transposase InsH for insertion sequence element IS5F | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | IS5 family transposase | P0CE53 Transposase InsH for insertion sequence element IS5H | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | IS5 family transposase | P0CE54 Transposase InsH for insertion sequence element IS5I | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | IS5 family transposase | P76071 Transposase InsH for insertion sequence element IS5Y | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase InsH, N-terminal | A0A385XJE6 Transposase InsH for insertion sequence element IS5U | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase InsH, N-terminal | P0CE49 Transposase InsH for insertion sequence element IS5A | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase InsH, N-terminal | P0CE50 Transposase InsH for insertion sequence element IS5B | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase InsH, N-terminal | P0CE51 Transposase InsH for insertion sequence element IS5D | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase InsH, N-terminal | P0CE52 Transposase InsH for insertion sequence element IS5F | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase InsH, N-terminal | P0CE53 Transposase InsH for insertion sequence element IS5H | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase InsH, N-terminal | P0CE54 Transposase InsH for insertion sequence element IS5I | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase InsH, N-terminal | P76071 Transposase InsH for insertion sequence element IS5Y | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase InsH, N-terminal | trait identifier | |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase IS4-like domain | A0A385XJE6 Transposase InsH for insertion sequence element IS5U | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase IS4-like domain | P0CE49 Transposase InsH for insertion sequence element IS5A | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase IS4-like domain | P0CE50 Transposase InsH for insertion sequence element IS5B | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase IS4-like domain | P0CE51 Transposase InsH for insertion sequence element IS5D | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase IS4-like domain | P0CE52 Transposase InsH for insertion sequence element IS5F | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase IS4-like domain | P0CE53 Transposase InsH for insertion sequence element IS5H | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase IS4-like domain | P0CE54 Transposase InsH for insertion sequence element IS5I | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase IS4-like domain | P76071 Transposase InsH for insertion sequence element IS5Y | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase DDE domain | P0CE49 Transposase InsH for insertion sequence element IS5A | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase DDE domain | P0CE51 Transposase InsH for insertion sequence element IS5D | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase domain (DUF772) | P0CE49 Transposase InsH for insertion sequence element IS5A | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase domain (DUF772) | P0CE51 Transposase InsH for insertion sequence element IS5D | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase domain (DUF772) | P0CE53 Transposase InsH for insertion sequence element IS5H | canonical example family classification |
| DUF772 (PF05598) | ProteinTraitsMech | Transposase domain (DUF772) | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.