DUFMech

All families / PF06025

PF06025: DUF913

Domain of Unknown Function (DUF913)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF06025: Domain of Unknown Function (DUF913)
IPR010314: integrated entry for Domain of Unknown Function (DUF913)

Source description

Members of this family are found in various ubiquitin protein ligases.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

4 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
P51593E3 ubiquitin-protein ligase HUWE1
Rattus norvegicus
4454 aa; version 3
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q03280E3 ubiquitin-protein ligase TOM1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
3268 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
2 sibling references
Q7TMY8E3 ubiquitin-protein ligase HUWE1
Mus musculus
4377 aa; version 5
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q7Z6Z7E3 ubiquitin-protein ligase HUWE1
Homo sapiens
4374 aa; version 3
UniProt 2026_03
PTM REGISTRY MIRROR
4 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
5,188
matches
5,279
proteomes
2,798
taxa
7,364
structures
13
alphafold models
344
domain architectures
219

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF913 (PF06025)ProteinTraitsMechE3 ubiquitin ligase, domain of unknown function DUF913
trait identifier
DUF913 (PF06025)ProteinTraitsMechDomain of Unknown Function (DUF908)Q03280
E3 ubiquitin-protein ligase TOM1
canonical example family classification
DUF913 (PF06025)ProteinTraitsMechDomain of Unknown Function (DUF908)Q7TMY8
E3 ubiquitin-protein ligase HUWE1
canonical example family classification
DUF913 (PF06025)ProteinTraitsMechDomain of Unknown Function (DUF908)Q7Z6Z7
E3 ubiquitin-protein ligase HUWE1
canonical example family classification
DUF913 (PF06025)ProteinTraitsMechDomain of Unknown Function (DUF913)P51593
E3 ubiquitin-protein ligase HUWE1
canonical example family classification
DUF913 (PF06025)ProteinTraitsMechDomain of Unknown Function (DUF913)Q7TMY8
E3 ubiquitin-protein ligase HUWE1
canonical example family classification
DUF913 (PF06025)ProteinTraitsMechDomain of Unknown Function (DUF913)Q7Z6Z7
E3 ubiquitin-protein ligase HUWE1
canonical example family classification
DUF913 (PF06025)ProteinTraitsMechDomain of Unknown Function (DUF913)
trait identifier
DUF913 (PF06025)ProteinTraitsMechUbiquitin binding regionQ7Z6Z7
E3 ubiquitin-protein ligase HUWE1
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF06025.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.