PF06244: Ccdc124

Coiled-coil domain-containing protein 124 /Oxs1

Curation status: SEEDED
Seed status: EX DUF
Characterization: UNSCORED

Grounding

PF06244: Coiled-coil domain-containing protein 124 /Oxs1
IPR054414: integrated entry for Coiled-coil domain-containing protein 124 /Oxs1

Source description

Oxs1 (oxidative stress transcription corepressor Oxs1) and Pap1 form a complex to regulate transcription when cells are exposed to diamide or Cd that causes disulfide stress. In fission yeast such as S. pombe, heterologous Oxs1-like proteins can enhance diamide stress tolerance. Furthermore, human and arabidopsis Oxs1 can interchangeably bind Pap1 or Pap1 homologues from human (cJun) and arabidopsis (bZIP10), suggesting that Oxs1 may be a component of an evolutionarily-conserved stress response pathway [InterPro reference PUB00091062]. Family members found in human such as Ccdc124 (Coiled-Coil Domain Containing Protein 124), were identified as a novel component of the centrosome during interphase and G2/M transition and is involved in cytokinesis [InterPro reference PUB00091062,InterPro reference PUB00073830].

Evidence and references

InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
Frozen description source: InterPro/Pfam API

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

4 verified sequence examples. FASTA

UniProt	Protein / organism	Sequence	Provenance
O94389	Coiled-coil domain-containing protein 124 homolog Schizosaccharomyces pombe (strain 972 / ATCC 24843)	207 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF06244
Q2TBV6	Coiled-coil domain-containing protein 124 Bos taurus	223 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF06244
Q96CT7	Coiled-coil domain-containing protein 124 Homo sapiens	223 aa; version 1 UniProt 2026_03	PTM REGISTRY MIRROR 3 sibling references ProteinTraitsMech: InterPro:IPR054414 ProteinTraitsMech: Pfam:PF06244 ProteinTraitsMech: UniProtKB:Q96CT7
Q9D8X2	Coiled-coil domain-containing protein 124 Mus musculus	217 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: InterPro:IPR054414

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins: 3,669
matches: 3,679
proteomes: 3,093
taxa: 8,262
structures: 5
alphafold models: 3,137
domain architectures: 61

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF06244.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.