DUFMech

All families / PF06280

PF06280: fn3_5

Fn3-like domain

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF06280: Fn3-like domain
IPR010435: integrated entry for Fn3-like domain

Source description

Fn3_5 is an fn3-like domain which is frequently found as the first of three on streptococcal C5a peptidase (SCP), a highly specific protease and adhesin/invasin. The family is found in conjunction with PF00082 (Pfam entry), PF02225 (Pfam entry) and PF00746 (Pfam entry) [InterPro reference PUB00046871].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

7 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
J9VDC2ProQSP1 protease 1
Cryptococcus neoformans (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)		951 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P0DD35C5a peptidase
Streptococcus pyogenes serotype M3 (strain SSI-1)		1169 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
P15292PIII-type proteinase
Lactococcus lactis subsp. cremoris (strain SK11)		1962 aa; version 2
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P15293PII-type proteinase
Lactococcus lactis subsp. cremoris		1902 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
P15926C5a peptidase
Streptococcus pyogenes		1167 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q02470PII-type proteinase
Lacticaseibacillus paracasei		1902 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q8NZ80C5a peptidase
Streptococcus pyogenes serotype M18 (strain MGAS8232)		1150 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
5,269
matches
5,272
proteomes
1,996
taxa
3,896
structures
10
alphafold models
3,614
domain architectures
282

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF06280.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.