PF06327: Adcy_cons_dom

Adenylate cyclase, conserved domain

Curation status: SEEDED
Seed status: EX DUF
Characterization: UNSCORED

Grounding

PF06327: Adenylate cyclase, conserved domain
IPR009398: integrated entry for Adenylate cyclase, conserved domain

Source description

Adenylate cyclase (AC) enzyme uses ATP as its substrate to produce Cyclic AMP (cAMP), a ubiquitous signalling molecule that mediates many cellular processes by activating cAMP- dependent kinases and also inducing protein-protein interactions. Mammalian adenylate cyclase has nine closely related membrane-bound isoforms (AC1-9) showing significant sequence homology and sharing the same overall structure: two hydrophobic transmembrane domains, and two cytoplasmic domains that are responsible for the catalytic activity. These isoforms differ in both their tissue specificity and their regulation [InterPro reference PUB00034664,InterPro reference PUB00034665]. This entry represents a region of unknown function found in many of these isoforms. It is part of the N-terminal cytoplasmic domain but its presence is not necessary for catalytic activity [InterPro reference PUB00034666].

Evidence and references

InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
Frozen description source: InterPro/Pfam API

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

11 verified sequence examples. FASTA

UniProt	Protein / organism	Sequence	Provenance
O43306	Adenylate cyclase type 6 Homo sapiens	1168 aa; version 2 UniProt 2026_03	PTM REGISTRY MIRROR 7 sibling references ProteinTraitsMech: GO:0007192 ProteinTraitsMech: GO:1904117 ProteinTraitsMech: GO:0035811 ProteinTraitsMech: InterPro:IPR009398 ProteinTraitsMech: InterPro:IPR032628 ProteinTraitsMech: Pfam:PF06327 ProteinTraitsMech: UniProtKB:O43306
O95622	Adenylate cyclase type 5 Homo sapiens	1261 aa; version 3 UniProt 2026_03	UNIPROT FETCH 5 sibling references ProteinTraitsMech: CDD:cd07556 ProteinTraitsMech: Pfam:PF00211 ProteinTraitsMech: Pfam:PF16214 ProteinTraitsMech: Pfam:PF06327 ProteinTraitsMech: PROSITE:PS00452
P32870	Adenylate cyclase 1 Drosophila melanogaster	2248 aa; version 2 UniProt 2026_03	UNIPROT FETCH 12 sibling references ProteinTraitsMech: GO:0004016 ProteinTraitsMech: GO:0008294 ProteinTraitsMech: GO:0007615 ProteinTraitsMech: GO:0001661 ProteinTraitsMech: GO:0007619 ProteinTraitsMech: GO:0009190 ProteinTraitsMech: GO:0072375 ProteinTraitsMech: GO:0007591 ProteinTraitsMech: GO:0090328 ProteinTraitsMech: InterPro:IPR018297 ProteinTraitsMech: InterPro:IPR009398 ProteinTraitsMech: InterPro:IPR032628
P40145	Adenylate cyclase type 8 Homo sapiens	1251 aa; version 1 UniProt 2026_03	UNIPROT FETCH 18 sibling references ProteinTraitsMech: GO:0004016 ProteinTraitsMech: GO:0008294 ProteinTraitsMech: GO:0034199 ProteinTraitsMech: GO:1904322 ProteinTraitsMech: GO:0071377 ProteinTraitsMech: GO:0071315 ProteinTraitsMech: GO:0038003 ProteinTraitsMech: GO:1900454 ProteinTraitsMech: GO:0031915 ProteinTraitsMech: GO:0003091 ProteinTraitsMech: GO:0097700 ProteinTraitsMech: InterPro:IPR018297 ProteinTraitsMech: InterPro:IPR009398 ProteinTraitsMech: InterPro:IPR032628 ProteinTraitsMech: Pfam:PF00211 ProteinTraitsMech: Pfam:PF16214 ProteinTraitsMech: Pfam:PF06327 ProteinTraitsMech: PROSITE:PS00452
P51828	Adenylate cyclase type 7 Homo sapiens	1080 aa; version 1 UniProt 2026_03	UNIPROT FETCH 2 sibling references ProteinTraitsMech: GO:0106408 ProteinTraitsMech: InterPro:IPR009398
P51829	Adenylate cyclase type 7 Mus musculus	1099 aa; version 2 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: GO:0106408
P84309	Adenylate cyclase type 5 Mus musculus	1262 aa; version 2 UniProt 2026_03	UNIPROT FETCH 3 sibling references ProteinTraitsMech: GO:0008294 ProteinTraitsMech: CDD:cd07556 ProteinTraitsMech: InterPro:IPR009398
P97490	Adenylate cyclase type 8 Mus musculus	1249 aa; version 2 UniProt 2026_03	UNIPROT FETCH 9 sibling references ProteinTraitsMech: GO:0004016 ProteinTraitsMech: GO:0008294 ProteinTraitsMech: GO:0034199 ProteinTraitsMech: GO:0071377 ProteinTraitsMech: GO:0071315 ProteinTraitsMech: GO:1900454 ProteinTraitsMech: InterPro:IPR018297 ProteinTraitsMech: InterPro:IPR009398 ProteinTraitsMech: InterPro:IPR032628
Q01341	Adenylate cyclase type 6 Mus musculus	1165 aa; version 1 UniProt 2026_03	UNIPROT FETCH 5 sibling references ProteinTraitsMech: GO:0008294 ProteinTraitsMech: GO:0007192 ProteinTraitsMech: GO:0072660 ProteinTraitsMech: GO:0035811 ProteinTraitsMech: InterPro:IPR009398
Q08462	Adenylate cyclase type 2 Homo sapiens	1091 aa; version 5 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: InterPro:IPR009398

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins: 8,560
matches: 8,592
proteomes: 1,178
taxa: 3,902
structures: 4
alphafold models: 6,799
domain architectures: 63

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF06327.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.