All families / PF06465
PF06465: DUF1087
CHD subfamily II, DUF1087
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF06465: CHD subfamily II, DUF1087
IPR009463: integrated entry for CHD subfamily II, DUF1087
Source description
This domain is found in chromatin remodelling factors (CHDs) from subfamily II [InterPro reference PUB00098174] including CHD3/4/5 from animals and PICKLE. from Arabidopsis. The exact function is, as yet, unknown.
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
4 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A2A8L1 | ATP-dependent chromatin remodeler CHD5 Mus musculus | 1946 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR1 sibling references |
| Q12873 | ATP-dependent chromatin remodeler CHD3 Homo sapiens | 2000 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| Q14839 | ATP-dependent chromatin remodeler CHD4 Homo sapiens | 1912 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q8TDI0 | ATP-dependent chromatin remodeler CHD5 Homo sapiens | 1954 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 7,326
- matches
- 7,329
- proteomes
- 1,594
- taxa
- 5,059
- structures
- 2
- alphafold models
- 432
- domain architectures
- 196
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF1087 (PF06465) | ProteinTraitsMech | Domain of unknown function DUF1087 | trait identifier | |
| DUF1087 (PF06465) | ProteinTraitsMech | CHDCT2 (NUC038) domain | Q12873 ATP-dependent chromatin remodeler CHD3 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | CHDCT2 (NUC038) domain | Q14839 ATP-dependent chromatin remodeler CHD4 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | CHDCT2 (NUC038) domain | Q8TDI0 ATP-dependent chromatin remodeler CHD5 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | CHD subfamily II, SANT-like domain | Q12873 ATP-dependent chromatin remodeler CHD3 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | CHD subfamily II, SANT-like domain | Q14839 ATP-dependent chromatin remodeler CHD4 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | CHD subfamily II, SANT-like domain | Q8TDI0 ATP-dependent chromatin remodeler CHD5 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | CHDNT (NUC034) domain | Q12873 ATP-dependent chromatin remodeler CHD3 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | CHDNT (NUC034) domain | Q14839 ATP-dependent chromatin remodeler CHD4 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | CHDNT (NUC034) domain | Q8TDI0 ATP-dependent chromatin remodeler CHD5 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | Chromo (CHRromatin Organisation MOdifier) domain | Q14839 ATP-dependent chromatin remodeler CHD4 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | CHD subfamily II, DUF1087 | Q12873 ATP-dependent chromatin remodeler CHD3 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | CHD subfamily II, DUF1087 | Q14839 ATP-dependent chromatin remodeler CHD4 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | CHD subfamily II, DUF1087 | Q8TDI0 ATP-dependent chromatin remodeler CHD5 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | CHD subfamily II, DUF1087 | trait identifier | |
| DUF1087 (PF06465) | ProteinTraitsMech | Chromo domain signature | Q14839 ATP-dependent chromatin remodeler CHD4 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | DEAH-box subfamily ATP-dependent helicases signature | Q14839 ATP-dependent chromatin remodeler CHD4 | canonical example family classification |
| DUF1087 (PF06465) | ProteinTraitsMech | Zinc finger PHD-type signature | Q14839 ATP-dependent chromatin remodeler CHD4 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.