DUFMech

All families / PF06465

PF06465: DUF1087

CHD subfamily II, DUF1087

Curation status
SEEDED
Seed status
KNOWN HISTORICAL DUF
Characterization
UNSCORED

Grounding

PF06465: CHD subfamily II, DUF1087
IPR009463: integrated entry for CHD subfamily II, DUF1087

Source description

This domain is found in chromatin remodelling factors (CHDs) from subfamily II [InterPro reference PUB00098174] including CHD3/4/5 from animals and PICKLE. from Arabidopsis. The exact function is, as yet, unknown.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

4 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
A2A8L1ATP-dependent chromatin remodeler CHD5
Mus musculus
1946 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
1 sibling references
Q12873ATP-dependent chromatin remodeler CHD3
Homo sapiens
2000 aa; version 3
UniProt 2026_03
UNIPROT FETCH
4 sibling references
Q14839ATP-dependent chromatin remodeler CHD4
Homo sapiens
1912 aa; version 2
UniProt 2026_03
UNIPROT FETCH
8 sibling references
Q8TDI0ATP-dependent chromatin remodeler CHD5
Homo sapiens
1954 aa; version 1
UniProt 2026_03
UNIPROT FETCH
4 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
7,326
matches
7,329
proteomes
1,594
taxa
5,059
structures
2
alphafold models
432
domain architectures
196

Classification basis

short name matches duf

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF1087 (PF06465)ProteinTraitsMechDomain of unknown function DUF1087
trait identifier
DUF1087 (PF06465)ProteinTraitsMechCHDCT2 (NUC038) domainQ12873
ATP-dependent chromatin remodeler CHD3
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechCHDCT2 (NUC038) domainQ14839
ATP-dependent chromatin remodeler CHD4
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechCHDCT2 (NUC038) domainQ8TDI0
ATP-dependent chromatin remodeler CHD5
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechCHD subfamily II, SANT-like domainQ12873
ATP-dependent chromatin remodeler CHD3
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechCHD subfamily II, SANT-like domainQ14839
ATP-dependent chromatin remodeler CHD4
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechCHD subfamily II, SANT-like domainQ8TDI0
ATP-dependent chromatin remodeler CHD5
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechCHDNT (NUC034) domainQ12873
ATP-dependent chromatin remodeler CHD3
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechCHDNT (NUC034) domainQ14839
ATP-dependent chromatin remodeler CHD4
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechCHDNT (NUC034) domainQ8TDI0
ATP-dependent chromatin remodeler CHD5
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechChromo (CHRromatin Organisation MOdifier) domainQ14839
ATP-dependent chromatin remodeler CHD4
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechCHD subfamily II, DUF1087Q12873
ATP-dependent chromatin remodeler CHD3
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechCHD subfamily II, DUF1087Q14839
ATP-dependent chromatin remodeler CHD4
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechCHD subfamily II, DUF1087Q8TDI0
ATP-dependent chromatin remodeler CHD5
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechCHD subfamily II, DUF1087
trait identifier
DUF1087 (PF06465)ProteinTraitsMechChromo domain signatureQ14839
ATP-dependent chromatin remodeler CHD4
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechDEAH-box subfamily ATP-dependent helicases signatureQ14839
ATP-dependent chromatin remodeler CHD4
canonical example family classification
DUF1087 (PF06465)ProteinTraitsMechZinc finger PHD-type signatureQ14839
ATP-dependent chromatin remodeler CHD4
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF06465.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.