All families / PF07142
PF07142: DUF1388
Repeat of unknown function (DUF1388)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF07142: Repeat of unknown function (DUF1388)
IPR010790: integrated entry for Repeat of unknown function (DUF1388)
Source description
This family consists of several repeats of around 29 residues in length. Members of this family are found in the variable surface lipoproteins in Mycoplasma bovis and in mammalian neurofilament triplet H (NefH or NF-H) proteins. This repeat contains several Lys-Ser-Pro (KSP) motifs and in NefH these are thought to function as the main target for neurofilament directed protein kinases in vivo [InterPro reference PUB00013013].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| P12036 | Neurofilament heavy polypeptide Homo sapiens | 1020 aa; version 5 UniProt 2026_03 | PTM REGISTRY MIRROR |
| P16884 | Neurofilament heavy polypeptide Rattus norvegicus | 1072 aa; version 4 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P19246 | Neurofilament heavy polypeptide Mus musculus | 1090 aa; version 3 UniProt 2026_03 | UNIPROT FETCH12 sibling references
|
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 311
- matches
- 746
- proteomes
- 189
- taxa
- 748
- structures
- 0
- alphafold models
- 226
- domain architectures
- 37
Classification basis
short name matches duf; name says unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF1388 (PF07142) | ProteinTraitsMech | basal proximal dendrite | P19246 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | neurofibrillary tangle | P12036 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | neurofibrillary tangle | P19246 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | postsynaptic intermediate filament cytoskeleton | P12036 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | postsynaptic intermediate filament cytoskeleton | P19246 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | structural constituent of postsynaptic intermediate filament cytoskeleton | P12036 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | structural constituent of postsynaptic intermediate filament cytoskeleton | P19246 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | intermediate filament bundle assembly | P19246 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | neurofilament bundle assembly | P12036 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | neurofilament bundle assembly | P19246 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | ovarian follicle atresia | P19246 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | peripheral nervous system neuron axonogenesis | P19246 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | regulation of organelle transport along microtubule | P19246 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | response to sodium arsenite | P19246 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | Repeat of unknown function DUF1388 | P12036 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | Repeat of unknown function DUF1388 | P19246 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | Repeat of unknown function DUF1388 | trait identifier | |
| DUF1388 (PF07142) | ProteinTraitsMech | Repeat of unknown function (DUF1388) | P12036 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | Repeat of unknown function (DUF1388) | P16884 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | Repeat of unknown function (DUF1388) | P19246 Neurofilament heavy polypeptide | canonical example family classification |
| DUF1388 (PF07142) | ProteinTraitsMech | Repeat of unknown function (DUF1388) | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.