DUFMech

All families / PF07142

PF07142: DUF1388

Repeat of unknown function (DUF1388)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF07142: Repeat of unknown function (DUF1388)
IPR010790: integrated entry for Repeat of unknown function (DUF1388)

Source description

This family consists of several repeats of around 29 residues in length. Members of this family are found in the variable surface lipoproteins in Mycoplasma bovis and in mammalian neurofilament triplet H (NefH or NF-H) proteins. This repeat contains several Lys-Ser-Pro (KSP) motifs and in NefH these are thought to function as the main target for neurofilament directed protein kinases in vivo [InterPro reference PUB00013013].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

3 verified sequence examples. FASTA

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
311
matches
746
proteomes
189
taxa
748
structures
0
alphafold models
226
domain architectures
37

Classification basis

short name matches duf; name says unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF1388 (PF07142)ProteinTraitsMechbasal proximal dendriteP19246
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechneurofibrillary tangleP12036
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechneurofibrillary tangleP19246
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechpostsynaptic intermediate filament cytoskeletonP12036
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechpostsynaptic intermediate filament cytoskeletonP19246
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechstructural constituent of postsynaptic intermediate filament cytoskeletonP12036
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechstructural constituent of postsynaptic intermediate filament cytoskeletonP19246
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechintermediate filament bundle assemblyP19246
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechneurofilament bundle assemblyP12036
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechneurofilament bundle assemblyP19246
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechovarian follicle atresiaP19246
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechperipheral nervous system neuron axonogenesisP19246
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechregulation of organelle transport along microtubuleP19246
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechresponse to sodium arseniteP19246
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechRepeat of unknown function DUF1388P12036
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechRepeat of unknown function DUF1388P19246
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechRepeat of unknown function DUF1388
trait identifier
DUF1388 (PF07142)ProteinTraitsMechRepeat of unknown function (DUF1388)P12036
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechRepeat of unknown function (DUF1388)P16884
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechRepeat of unknown function (DUF1388)P19246
Neurofilament heavy polypeptide
canonical example family classification
DUF1388 (PF07142)ProteinTraitsMechRepeat of unknown function (DUF1388)
trait identifier

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF07142.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.