All families / PF07469
PF07469: DUF1518
Nuclear receptor coactivator, DUF1518
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF07469: Nuclear receptor coactivator, DUF1518
IPR010011: integrated entry for Nuclear receptor coactivator, DUF1518
Source description
This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors [InterPro reference PUB00097822,InterPro reference PUB00069373].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
4 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O09000 | Nuclear receptor coactivator 3 Mus musculus | 1398 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q15596 | Nuclear receptor coactivator 2 Homo sapiens | 1464 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q15788 | Nuclear receptor coactivator 1 Homo sapiens | 1441 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| Q9Y6Q9 | Nuclear receptor coactivator 3 Homo sapiens | 1424 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 2,780
- matches
- 3,753
- proteomes
- 701
- taxa
- 2,146
- structures
- 0
- alphafold models
- 226
- domain architectures
- 62
Classification basis
short name matches duf; description says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF1518 (PF07469) | ProteinTraitsMech | Unstructured region on nuclear receptor coactivator protein | Q15596 Nuclear receptor coactivator 2 | canonical example family classification |
| DUF1518 (PF07469) | ProteinTraitsMech | Unstructured region on nuclear receptor coactivator protein | Q15788 Nuclear receptor coactivator 1 | canonical example family classification |
| DUF1518 (PF07469) | ProteinTraitsMech | Unstructured region on nuclear receptor coactivator protein | Q9Y6Q9 Nuclear receptor coactivator 3 | canonical example family classification |
| DUF1518 (PF07469) | ProteinTraitsMech | Nuclear receptor coactivator, DUF1518 | trait identifier | |
| DUF1518 (PF07469) | ProteinTraitsMech | Nuclear receptor coactivators bHLH domain | Q15596 Nuclear receptor coactivator 2 | canonical example family classification |
| DUF1518 (PF07469) | ProteinTraitsMech | Nuclear receptor coactivators bHLH domain | Q15788 Nuclear receptor coactivator 1 | canonical example family classification |
| DUF1518 (PF07469) | ProteinTraitsMech | Nuclear receptor coactivators bHLH domain | Q9Y6Q9 Nuclear receptor coactivator 3 | canonical example family classification |
| DUF1518 (PF07469) | ProteinTraitsMech | Nuclear receptor coactivator, DUF1518 | Q15596 Nuclear receptor coactivator 2 | canonical example family classification |
| DUF1518 (PF07469) | ProteinTraitsMech | Nuclear receptor coactivator, DUF1518 | Q15788 Nuclear receptor coactivator 1 | canonical example family classification |
| DUF1518 (PF07469) | ProteinTraitsMech | Nuclear receptor coactivator, DUF1518 | Q9Y6Q9 Nuclear receptor coactivator 3 | canonical example family classification |
| DUF1518 (PF07469) | ProteinTraitsMech | Nuclear receptor coactivator, DUF1518 | trait identifier | |
| DUF1518 (PF07469) | ProteinTraitsMech | Domain of unknown function (DUF4927) | O09000 Nuclear receptor coactivator 3 | canonical example family classification |
| DUF1518 (PF07469) | ProteinTraitsMech | Domain of unknown function (DUF4927) | Q15596 Nuclear receptor coactivator 2 | canonical example family classification |
| DUF1518 (PF07469) | ProteinTraitsMech | Domain of unknown function (DUF4927) | Q9Y6Q9 Nuclear receptor coactivator 3 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.