PF07894: SACK1

Scaffolding anchor of CK1 domain

Curation status: SEEDED
Seed status: EX DUF
Characterization: UNSCORED

Grounding

PF07894: Scaffolding anchor of CK1 domain
IPR012461: integrated entry for Scaffolding anchor of CK1 domain

Source description

This entry represents the scaffolding anchor of CK1 domain (SACK1 domain) found in the FAM83 family, which includes FAM83A-H. This domain was formerly known as DUF1669 and it has been identified as a CK1 binding domain, which allows the correct subcellular localisation of both FAM83 proteins and the CK1 binding partners and their function [InterPro reference PUB00155374]. These proteins are involved in diverse biological processes, depending on their subcellular localisation and binding partners. FAM83A-H interact with the alpha and alpha-like isoforms of CK1, while FAM83A, B, E, and H also interact with the delta and epsilon isoforms of CK1. FAM83 members have function as intermediaries in EGFR/RAS signalling [InterPro reference PUB00084963]. FAM83D has been reported to localise to the mitotic spindle and interact with the chromokinesin kinesin family member 22 (KIF22, also called Kid) [InterPro reference PUB00124155]. FAM83G, also known as PAWS1 interacts with the transcription factor SMAD1 and promotes the transcription of non-canonical bone morphogenetic protein (BMP) target genes [InterPro reference PUB00155375]. FAM83H mutations have been associated with amelogenesis imperfecta [InterPro reference PUB00092186].

Evidence and references

InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
Frozen description source: InterPro/Pfam API

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

12 verified sequence examples. FASTA

UniProt	Protein / organism	Sequence	Provenance
A6ND36	Scaffolding CK1 anchoring protein G Homo sapiens	823 aa; version 2 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: CDD:cd09187
Q0VBM2	Scaffolding CK1 anchoring protein B Mus musculus	1012 aa; version 1 UniProt 2026_03	UNIPROT FETCH 4 sibling references ProteinTraitsMech: GO:0036313 ProteinTraitsMech: CDD:cd09182 ProteinTraitsMech: InterPro:IPR012461 ProteinTraitsMech: Pfam:PF07894
Q148V8	Scaffolding CK1 anchoring protein H Mus musculus	1209 aa; version 1 UniProt 2026_03	UNIPROT FETCH 5 sibling references ProteinTraitsMech: GO:0044380 ProteinTraitsMech: CDD:cd09188 ProteinTraitsMech: InterPro:IPR041996 ProteinTraitsMech: InterPro:IPR012461 ProteinTraitsMech: Pfam:PF07894
Q3UKU4	Scaffolding CK1 anchoring protein F Mus musculus	495 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: CDD:cd09186
Q5T0W9	Scaffolding CK1 anchoring protein B Homo sapiens	1011 aa; version 1 UniProt 2026_03	PTM REGISTRY MIRROR 5 sibling references ProteinTraitsMech: GO:0036313 ProteinTraitsMech: CDD:cd09182 ProteinTraitsMech: InterPro:IPR012461 ProteinTraitsMech: Pfam:PF07894 ProteinTraitsMech: UniProtKB:Q5T0W9
Q6ZRV2	Scaffolding CK1 anchoring protein H Homo sapiens	1179 aa; version 3 UniProt 2026_03	UNIPROT FETCH 5 sibling references ProteinTraitsMech: GO:0044380 ProteinTraitsMech: CDD:cd09188 ProteinTraitsMech: InterPro:IPR041996 ProteinTraitsMech: InterPro:IPR012461 ProteinTraitsMech: Pfam:PF07894
Q86UY5	Scaffolding CK1 anchoring protein A Homo sapiens	434 aa; version 1 UniProt 2026_03	UNIPROT FETCH 3 sibling references ProteinTraitsMech: CDD:cd09181 ProteinTraitsMech: InterPro:IPR012461 ProteinTraitsMech: Pfam:PF07894
Q8K2P2	Scaffolding CK1 anchoring protein A Mus musculus	436 aa; version 2 UniProt 2026_03	UNIPROT FETCH 3 sibling references ProteinTraitsMech: CDD:cd09181 ProteinTraitsMech: InterPro:IPR012461 ProteinTraitsMech: Pfam:PF07894
Q8NEG4	Scaffolding CK1 anchoring protein F Homo sapiens	500 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: CDD:cd09186
Q9BQN1	Scaffolding CK1 anchoring protein C Homo sapiens	747 aa; version 3 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: CDD:cd09183

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins: 7,127
matches: 7,530
proteomes: 767
taxa: 2,356
structures: 13
alphafold models: 6,117
domain architectures: 43

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF07894.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.