DUFMech

All families / PF08226

PF08226: DUF1720

Domain of unknown function (DUF1720)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF08226: Domain of unknown function (DUF1720)
IPR013182: integrated entry for Domain of unknown function (DUF1720)

Source description

This domain is found in different combinations with cortical patch components EF hand, SH3 and ENTH and is therefore likely to be involved in cytoskeletal processes. This family contains many hypothetical proteins.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

3 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O74423Epsin-1
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
702 aa; version 2
UniProt 2026_03
UNIPROT FETCH
1 sibling references
P32521Actin cytoskeleton-regulatory complex protein PAN1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
1480 aa; version 2
UniProt 2026_03
PTM REGISTRY MIRROR
10 sibling references
Q5ALV2Actin cytoskeleton-regulatory complex protein SLA1
Candida albicans (strain SC5314 / ATCC MYA-2876)
1257 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
1,675
matches
1,877
proteomes
1,014
taxa
2,308
structures
0
alphafold models
826
domain architectures
113

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF1720 (PF08226)AntibioticMechfluconazoleQ5ALV2
Actin cytoskeleton-regulatory complex protein SLA1
uniprot pfam xref
DUF1720 (PF08226)ProteinTraitsMechactin cytoskeleton-regulatory complexP32521
Actin cytoskeleton-regulatory complex protein PAN1
canonical example family classification
DUF1720 (PF08226)ProteinTraitsMechactin cortical patch assemblyP32521
Actin cytoskeleton-regulatory complex protein PAN1
canonical example family classification
DUF1720 (PF08226)ProteinTraitsMechaxial cellular bud site selectionP32521
Actin cytoskeleton-regulatory complex protein PAN1
canonical example family classification
DUF1720 (PF08226)ProteinTraitsMechbipolar cellular bud site selectionP32521
Actin cytoskeleton-regulatory complex protein PAN1
canonical example family classification
DUF1720 (PF08226)ProteinTraitsMechEHP32521
Actin cytoskeleton-regulatory complex protein PAN1
canonical example family classification
DUF1720 (PF08226)ProteinTraitsMechDomain of unknown function DUF1720P32521
Actin cytoskeleton-regulatory complex protein PAN1
canonical example family classification
DUF1720 (PF08226)ProteinTraitsMechDomain of unknown function DUF1720
trait identifier
DUF1720 (PF08226)ProteinTraitsMechEH domainP32521
Actin cytoskeleton-regulatory complex protein PAN1
canonical example family classification
DUF1720 (PF08226)ProteinTraitsMechDomain of unknown function (DUF1720)O74423
Epsin-1
canonical example family classification
DUF1720 (PF08226)ProteinTraitsMechDomain of unknown function (DUF1720)P32521
Actin cytoskeleton-regulatory complex protein PAN1
canonical example family classification
DUF1720 (PF08226)ProteinTraitsMechDomain of unknown function (DUF1720)Q5ALV2
Actin cytoskeleton-regulatory complex protein SLA1
canonical example family classification
DUF1720 (PF08226)ProteinTraitsMechDomain of unknown function (DUF1720)
trait identifier
DUF1720 (PF08226)ProteinTraitsMechEH domain profileP32521
Actin cytoskeleton-regulatory complex protein PAN1
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF08226.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.