DUFMech

All families / PF08338

PF08338: DUF1731

Domain of unknown function (DUF1731)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF08338: Domain of unknown function (DUF1731)
IPR013549: integrated entry for Domain of unknown function (DUF1731)

Source description

This domain of unknown function appears towards the C-terminus of proteins of the NAD dependent epimerase/dehydratase family (PF01370 (Pfam entry)) in bacteria, eukaryotes and archaea. Many of the proteins in which it is found are involved in cell-division inhibition.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

6 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O31574Epimerase family protein YfhF
Bacillus subtilis (strain 168)
303 aa; version 1
UniProt 2026_03
UNIPROT FETCH
3 sibling references
P77775Epimerase family protein YfcH
Escherichia coli (strain K12)
297 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
4 sibling references
Q17QH8Epimerase family protein SDR39U1
Bos taurus
294 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q5M8N4Epimerase family protein SDR39U1
Mus musculus
293 aa; version 2
UniProt 2026_03
UNIPROT FETCH
3 sibling references
Q9NRG7Epimerase family protein SDR39U1
Homo sapiens
293 aa; version 3
UniProt 2026_03
UNIPROT FETCH
4 sibling references
Q9SJU9Epimerase family protein SDR39U1 homolog, chloroplastic
Arabidopsis thaliana
347 aa; version 2
UniProt 2026_03
UNIPROT FETCH
5 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
15,266
matches
15,270
proteomes
12,014
taxa
19,138
structures
2
alphafold models
9,814
domain architectures
54

Classification basis

short name matches duf; name says unknown function; description says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF1731 (PF08338)ProteinTraitsMechthylakoid membrane protein ThyDQ9SJU9
Epimerase family protein SDR39U1 homolog, chloroplastic
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechTIGR01777 family oxidoreductaseO31574
Epimerase family protein YfhF
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechTIGR01777 family oxidoreductaseP77775
Epimerase family protein YfcH
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechTIGR01777 family oxidoreductaseQ5M8N4
Epimerase family protein SDR39U1
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechTIGR01777 family oxidoreductaseQ9NRG7
Epimerase family protein SDR39U1
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechTIGR01777 family oxidoreductaseQ9SJU9
Epimerase family protein SDR39U1 homolog, chloroplastic
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechSDR_a8O31574
Epimerase family protein YfhF
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechSDR_a8P77775
Epimerase family protein YfcH
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechSDR_a8Q5M8N4
Epimerase family protein SDR39U1
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechSDR_a8Q9NRG7
Epimerase family protein SDR39U1
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechSDR_a8Q9SJU9
Epimerase family protein SDR39U1 homolog, chloroplastic
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechDomain of unknown function DUF1731O31574
Epimerase family protein YfhF
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechDomain of unknown function DUF1731P77775
Epimerase family protein YfcH
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechDomain of unknown function DUF1731Q5M8N4
Epimerase family protein SDR39U1
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechDomain of unknown function DUF1731Q9NRG7
Epimerase family protein SDR39U1
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechDomain of unknown function DUF1731Q9SJU9
Epimerase family protein SDR39U1 homolog, chloroplastic
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechDomain of unknown function DUF1731
trait identifier
DUF1731 (PF08338)ProteinTraitsMechDomain of unknown function (DUF1731)Q17QH8
Epimerase family protein SDR39U1
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechDomain of unknown function (DUF1731)Q9NRG7
Epimerase family protein SDR39U1
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechDomain of unknown function (DUF1731)Q9SJU9
Epimerase family protein SDR39U1 homolog, chloroplastic
canonical example family classification
DUF1731 (PF08338)ProteinTraitsMechDomain of unknown function (DUF1731)
trait identifier

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF08338.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.