All families / PF08338
PF08338: DUF1731
Domain of unknown function (DUF1731)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF08338: Domain of unknown function (DUF1731)
IPR013549: integrated entry for Domain of unknown function (DUF1731)
Source description
This domain of unknown function appears towards the C-terminus of proteins of the NAD dependent epimerase/dehydratase family (PF01370 (Pfam entry)) in bacteria, eukaryotes and archaea. Many of the proteins in which it is found are involved in cell-division inhibition.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
6 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O31574 | Epimerase family protein YfhF Bacillus subtilis (strain 168) | 303 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| P77775 | Epimerase family protein YfcH Escherichia coli (strain K12) | 297 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q17QH8 | Epimerase family protein SDR39U1 Bos taurus | 294 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q5M8N4 | Epimerase family protein SDR39U1 Mus musculus | 293 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q9NRG7 | Epimerase family protein SDR39U1 Homo sapiens | 293 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| Q9SJU9 | Epimerase family protein SDR39U1 homolog, chloroplastic Arabidopsis thaliana | 347 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 15,266
- matches
- 15,270
- proteomes
- 12,014
- taxa
- 19,138
- structures
- 2
- alphafold models
- 9,814
- domain architectures
- 54
Classification basis
short name matches duf; name says unknown function; description says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF1731 (PF08338) | ProteinTraitsMech | thylakoid membrane protein ThyD | Q9SJU9 Epimerase family protein SDR39U1 homolog, chloroplastic | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | TIGR01777 family oxidoreductase | O31574 Epimerase family protein YfhF | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | TIGR01777 family oxidoreductase | P77775 Epimerase family protein YfcH | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | TIGR01777 family oxidoreductase | Q5M8N4 Epimerase family protein SDR39U1 | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | TIGR01777 family oxidoreductase | Q9NRG7 Epimerase family protein SDR39U1 | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | TIGR01777 family oxidoreductase | Q9SJU9 Epimerase family protein SDR39U1 homolog, chloroplastic | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | SDR_a8 | O31574 Epimerase family protein YfhF | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | SDR_a8 | P77775 Epimerase family protein YfcH | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | SDR_a8 | Q5M8N4 Epimerase family protein SDR39U1 | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | SDR_a8 | Q9NRG7 Epimerase family protein SDR39U1 | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | SDR_a8 | Q9SJU9 Epimerase family protein SDR39U1 homolog, chloroplastic | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | Domain of unknown function DUF1731 | O31574 Epimerase family protein YfhF | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | Domain of unknown function DUF1731 | P77775 Epimerase family protein YfcH | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | Domain of unknown function DUF1731 | Q5M8N4 Epimerase family protein SDR39U1 | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | Domain of unknown function DUF1731 | Q9NRG7 Epimerase family protein SDR39U1 | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | Domain of unknown function DUF1731 | Q9SJU9 Epimerase family protein SDR39U1 homolog, chloroplastic | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | Domain of unknown function DUF1731 | trait identifier | |
| DUF1731 (PF08338) | ProteinTraitsMech | Domain of unknown function (DUF1731) | Q17QH8 Epimerase family protein SDR39U1 | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | Domain of unknown function (DUF1731) | Q9NRG7 Epimerase family protein SDR39U1 | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | Domain of unknown function (DUF1731) | Q9SJU9 Epimerase family protein SDR39U1 homolog, chloroplastic | canonical example family classification |
| DUF1731 (PF08338) | ProteinTraitsMech | Domain of unknown function (DUF1731) | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.