All families / PF08512
PF08512: Rttp106-like_middle
Histone chaperone Rttp106-like, middle domain
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF08512: Histone chaperone Rttp106-like, middle domain
IPR013719: integrated entry for Histone chaperone Rttp106-like, middle domain
Source description
This Pleckstrin homology (PH) domain is found in the middle region of Rttp106, a histone chaperone involved in heterochromatin-mediated silencing [InterPro reference PUB00033392]. It is also found in the final part of the middle domain of various FACT (facilitates chromatin transactions) complex subunits, such as Spt16 and either Pob3 (yeast) or the related SSRP1 (higher eukaryotes). This domain plays a role in DNA binding [InterPro reference PUB00101033,InterPro reference PUB00101035,InterPro reference PUB00101032].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
10 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O01683 | FACT complex subunit ssrp1-B Caenorhabditis elegans | 689 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR2 sibling references |
| O82491 | FACT complex subunit SPT16 Arabidopsis thaliana | 1074 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR1 sibling references |
| P32558 | FACT complex subunit SPT16 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 1035 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P40161 | Histone chaperone RTT106 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 455 aa; version 1 UniProt 2026_03 | UNIPROT FETCH12 sibling references
|
| P41848 | FACT complex subunit SSRP1-A Caenorhabditis elegans | 697 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q05153 | FACT complex subunit SSRP1 Arabidopsis thaliana | 646 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q05344 | FACT complex subunit Ssrp1 Drosophila melanogaster | 723 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8IRG6 | FACT complex subunit spt16 Drosophila melanogaster | 1083 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q9N5R9 | FACT complex subunit spt-16 Caenorhabditis elegans | 1030 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q9Y5B9 | FACT complex subunit SPT16 Homo sapiens | 1047 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 10,226
- matches
- 10,251
- proteomes
- 3,420
- taxa
- 9,039
- structures
- 36
- alphafold models
- 8,633
- domain architectures
- 244
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.