DUFMech

All families / PF08590

PF08590: DUF1771

Domain of unknown function (DUF1771)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF08590: Domain of unknown function (DUF1771)
IPR013899: integrated entry for Domain of unknown function (DUF1771)

Source description

This domain is highly charged and may represent a small helical extension of the Smr domain (PF01713 (Pfam entry)), known as N-ext, whose function is not yet clear [InterPro reference PUB00098095].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

5 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O64843Polyadenylate-binding protein-interacting protein 7
Arabidopsis thaliana
567 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
9 sibling references
O65573SMR domain-containing protein At5g58720
Arabidopsis thaliana
519 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
8 sibling references
Q08954Endonuclease NBR9
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
240 aa; version 1
UniProt 2026_03
UNIPROT FETCH
7 sibling references
Q86UW6NEDD4-binding protein 2
Homo sapiens
1770 aa; version 2
UniProt 2026_03
PTM REGISTRY MIRROR
6 sibling references
Q9LUQ3Putative nuclear RNA export factor SDE5
Arabidopsis thaliana
490 aa; version 1
UniProt 2026_03
UNIPROT FETCH
5 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
7,421
matches
7,427
proteomes
2,861
taxa
7,508
structures
0
alphafold models
5,346
domain architectures
237

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF1771 (PF08590)ProteinTraitsMechCUE_CID7_likeO64843
Polyadenylate-binding protein-interacting protein 7
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechAt5g58720/SDE5-like, middle domainO65573
SMR domain-containing protein At5g58720
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechAt5g58720/SDE5-like, middle domainQ9LUQ3
Putative nuclear RNA export factor SDE5
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechAt5g58720/SDE5-like, UBA-like domainO65573
SMR domain-containing protein At5g58720
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechAt5g58720/SDE5-like, UBA-like domainQ9LUQ3
Putative nuclear RNA export factor SDE5
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechDomain of unknown function DUF1771O64843
Polyadenylate-binding protein-interacting protein 7
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechDomain of unknown function DUF1771O65573
SMR domain-containing protein At5g58720
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechDomain of unknown function DUF1771Q08954
Endonuclease NBR9
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechDomain of unknown function DUF1771Q9LUQ3
Putative nuclear RNA export factor SDE5
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechDomain of unknown function DUF1771
trait identifier
DUF1771 (PF08590)ProteinTraitsMechPolyadenylate-binding protein-interacting protein 5/6/7, CUE domainO64843
Polyadenylate-binding protein-interacting protein 7
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechSmr domainO64843
Polyadenylate-binding protein-interacting protein 7
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechSmr domainQ08954
Endonuclease NBR9
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechAAA domainQ86UW6
NEDD4-binding protein 2
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechDomain of unknown function (DUF1771)O64843
Polyadenylate-binding protein-interacting protein 7
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechDomain of unknown function (DUF1771)Q08954
Endonuclease NBR9
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechDomain of unknown function (DUF1771)Q86UW6
NEDD4-binding protein 2
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechDomain of unknown function (DUF1771)
trait identifier
DUF1771 (PF08590)ProteinTraitsMechDomain of unknown function (DUF7816)Q86UW6
NEDD4-binding protein 2
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechDomain of unknown function (DUF7817)Q86UW6
NEDD4-binding protein 2
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechDomain of unknown function (DUF7818)Q86UW6
NEDD4-binding protein 2
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechSmr domainQ08954
Endonuclease NBR9
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechAt5g58720 UBA-like domainO65573
SMR domain-containing protein At5g58720
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechAt5g58720 UBA-like domainQ9LUQ3
Putative nuclear RNA export factor SDE5
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechSDE5-like, UBA domainO65573
SMR domain-containing protein At5g58720
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechSDE5-like, UBA domainQ9LUQ3
Putative nuclear RNA export factor SDE5
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechSmr domain superfamilyO64843
Polyadenylate-binding protein-interacting protein 7
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechSmr domain superfamilyO65573
SMR domain-containing protein At5g58720
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechSmr domain superfamilyQ08954
Endonuclease NBR9
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechSmr domain profileO64843
Polyadenylate-binding protein-interacting protein 7
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechSmr domain profileQ08954
Endonuclease NBR9
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechCATH homologous superfamily 3.30.1370.110O64843
Polyadenylate-binding protein-interacting protein 7
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechCATH homologous superfamily 3.30.1370.110O65573
SMR domain-containing protein At5g58720
canonical example family classification
DUF1771 (PF08590)ProteinTraitsMechCATH homologous superfamily 3.30.1370.110Q08954
Endonuclease NBR9
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF08590.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.