All families / PF08590
PF08590: DUF1771
Domain of unknown function (DUF1771)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF08590: Domain of unknown function (DUF1771)
IPR013899: integrated entry for Domain of unknown function (DUF1771)
Source description
This domain is highly charged and may represent a small helical extension of the Smr domain (PF01713 (Pfam entry)), known as N-ext, whose function is not yet clear [InterPro reference PUB00098095].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
5 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O64843 | Polyadenylate-binding protein-interacting protein 7 Arabidopsis thaliana | 567 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR9 sibling references
|
| O65573 | SMR domain-containing protein At5g58720 Arabidopsis thaliana | 519 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR8 sibling references |
| Q08954 | Endonuclease NBR9 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 240 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q86UW6 | NEDD4-binding protein 2 Homo sapiens | 1770 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q9LUQ3 | Putative nuclear RNA export factor SDE5 Arabidopsis thaliana | 490 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 7,421
- matches
- 7,427
- proteomes
- 2,861
- taxa
- 7,508
- structures
- 0
- alphafold models
- 5,346
- domain architectures
- 237
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF1771 (PF08590) | ProteinTraitsMech | CUE_CID7_like | O64843 Polyadenylate-binding protein-interacting protein 7 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | At5g58720/SDE5-like, middle domain | O65573 SMR domain-containing protein At5g58720 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | At5g58720/SDE5-like, middle domain | Q9LUQ3 Putative nuclear RNA export factor SDE5 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | At5g58720/SDE5-like, UBA-like domain | O65573 SMR domain-containing protein At5g58720 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | At5g58720/SDE5-like, UBA-like domain | Q9LUQ3 Putative nuclear RNA export factor SDE5 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Domain of unknown function DUF1771 | O64843 Polyadenylate-binding protein-interacting protein 7 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Domain of unknown function DUF1771 | O65573 SMR domain-containing protein At5g58720 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Domain of unknown function DUF1771 | Q08954 Endonuclease NBR9 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Domain of unknown function DUF1771 | Q9LUQ3 Putative nuclear RNA export factor SDE5 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Domain of unknown function DUF1771 | trait identifier | |
| DUF1771 (PF08590) | ProteinTraitsMech | Polyadenylate-binding protein-interacting protein 5/6/7, CUE domain | O64843 Polyadenylate-binding protein-interacting protein 7 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Smr domain | O64843 Polyadenylate-binding protein-interacting protein 7 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Smr domain | Q08954 Endonuclease NBR9 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | AAA domain | Q86UW6 NEDD4-binding protein 2 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Domain of unknown function (DUF1771) | O64843 Polyadenylate-binding protein-interacting protein 7 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Domain of unknown function (DUF1771) | Q08954 Endonuclease NBR9 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Domain of unknown function (DUF1771) | Q86UW6 NEDD4-binding protein 2 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Domain of unknown function (DUF1771) | trait identifier | |
| DUF1771 (PF08590) | ProteinTraitsMech | Domain of unknown function (DUF7816) | Q86UW6 NEDD4-binding protein 2 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Domain of unknown function (DUF7817) | Q86UW6 NEDD4-binding protein 2 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Domain of unknown function (DUF7818) | Q86UW6 NEDD4-binding protein 2 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Smr domain | Q08954 Endonuclease NBR9 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | At5g58720 UBA-like domain | O65573 SMR domain-containing protein At5g58720 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | At5g58720 UBA-like domain | Q9LUQ3 Putative nuclear RNA export factor SDE5 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | SDE5-like, UBA domain | O65573 SMR domain-containing protein At5g58720 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | SDE5-like, UBA domain | Q9LUQ3 Putative nuclear RNA export factor SDE5 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Smr domain superfamily | O64843 Polyadenylate-binding protein-interacting protein 7 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Smr domain superfamily | O65573 SMR domain-containing protein At5g58720 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Smr domain superfamily | Q08954 Endonuclease NBR9 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Smr domain profile | O64843 Polyadenylate-binding protein-interacting protein 7 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | Smr domain profile | Q08954 Endonuclease NBR9 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | CATH homologous superfamily 3.30.1370.110 | O64843 Polyadenylate-binding protein-interacting protein 7 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | CATH homologous superfamily 3.30.1370.110 | O65573 SMR domain-containing protein At5g58720 | canonical example family classification |
| DUF1771 (PF08590) | ProteinTraitsMech | CATH homologous superfamily 3.30.1370.110 | Q08954 Endonuclease NBR9 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.