All families / PF08699
PF08699: ArgoL1
Argonaute linker 1 domain
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF08699: Argonaute linker 1 domain
IPR014811: integrated entry for Argonaute linker 1 domain
Source description
ArgoL1 is a region found in argonaute [InterPro reference PUB00035384] proteins. It normally co-occurs with PF02179 (Pfam entry) and PF02171 (Pfam entry). It is a linker region between the N-terminal and the PAZ domains. It contains an alpha-helix packed against a three-stranded antiparallel beta-sheet with two long beta-strands (beta8 and beta9) of the sheet spanning one face of the adjacent N and PAZ domains. L1 together with linker 2, L2, PAZ and ArgoN forms a compact global fold [InterPro reference PUB00038652].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
10 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O04379 | Protein argonaute 1 Arabidopsis thaliana | 1048 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR2 sibling references |
| Q6EU14 | Protein argonaute 1A Oryza sativa subsp. japonica | 1082 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q7XSA2 | Protein argonaute 1B Oryza sativa subsp. japonica | 1118 aa; version 3 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8CJG0 | Protein argonaute-2 Mus musculus | 860 aa; version 3 UniProt 2026_03 | PTM REGISTRY MIRROR1 sibling references |
| Q96J94 | Piwi-like protein 1 Homo sapiens | 861 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q9H9G7 | Protein argonaute-3 Homo sapiens | 860 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q9HCK5 | Protein argonaute-4 Homo sapiens | 861 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q9UKV8 | Protein argonaute-2 Homo sapiens | 859 aa; version 3 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9UL18 | Protein argonaute-1 Homo sapiens | 857 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| Q9VUQ5 | Protein argonaute-2 Drosophila melanogaster | 1214 aa; version 3 UniProt 2026_03 | PTM REGISTRY MIRROR1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 21,447
- matches
- 21,522
- proteomes
- 3,107
- taxa
- 8,566
- structures
- 74
- alphafold models
- 18,036
- domain architectures
- 419
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.