All families / PF08953
PF08953: DUF1899
Domain of unknown function (DUF1899)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF08953: Domain of unknown function (DUF1899)
IPR015048: integrated entry for Domain of unknown function (DUF1899)
Source description
This set of domains is found in various eukaryotic proteins. Function is unknown.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
12 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O89053 | Coronin-1A Mus musculus | 461 aa; version 5 UniProt 2026_03 | UNIPROT FETCH12 sibling references
|
| P31146 | Coronin-1A Homo sapiens | 461 aa; version 4 UniProt 2026_03 | PTM REGISTRY MIRROR |
| P57737 | Coronin-7 Homo sapiens | 925 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q06440 | Coronin-like protein Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 651 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q6QEF8 | Coronin-6 Homo sapiens | 472 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8BH44 | Coronin-2B Mus musculus | 480 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q92176 | Coronin-1A Bos taurus | 461 aa; version 3 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9BR76 | Coronin-1B Homo sapiens | 489 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9ULV4 | Coronin-1C Homo sapiens | 474 aa; version 1 UniProt 2026_03 | UNIPROT FETCH14 sibling references
|
| Q9UQ03 | Coronin-2B Homo sapiens | 480 aa; version 4 UniProt 2026_03 | UNIPROT FETCH |
First 10 shown; the FASTA and family JSON contain all examples.
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 12,107
- matches
- 13,193
- proteomes
- 2,919
- taxa
- 7,698
- structures
- 11
- alphafold models
- 10,516
- domain architectures
- 235
Classification basis
short name matches duf; name says unknown function; description says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF1899 (PF08953) | ProteinTraitsMech | stereocilium tip | O89053 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | myosin heavy chain binding | O89053 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | talin binding | Q8BH44 Coronin-2B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | talin binding | Q9UQ03 Coronin-2B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | actin cortical patch assembly | Q9WUM4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | actin filament branching | Q9BR76 Coronin-1B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | actin filament branching | Q9WUM3 Coronin-1B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | actin filament debranching | Q06440 Coronin-like protein | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | activation of GTPase activity | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | endosome fission | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | endosome fission | Q9WUM4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | endosome membrane tubulation | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | endosome membrane tubulation | Q9WUM4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | natural killer cell degranulation | O89053 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | negative regulation of actin nucleation | O89053 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | negative regulation of cellular component organization | Q6QEF8 Coronin-6 | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | negative regulation of epithelial cell migration | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | negative regulation of establishment of protein localization | Q8BH44 Coronin-2B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | negative regulation of establishment of protein localization | Q9UQ03 Coronin-2B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | negative regulation of lamellipodium morphogenesis | Q9WUM3 Coronin-1B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | negative regulation of protein kinase activity by regulation of protein phosphorylation | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | negative regulation of protein kinase activity by regulation of protein phosphorylation | Q9WUM4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | negative regulation of smooth muscle cell chemotaxis | Q9BR76 Coronin-1B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | negative regulation of smooth muscle cell chemotaxis | Q9WUM3 Coronin-1B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | negative regulation of substrate adhesion-dependent cell spreading | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | negative regulation of vesicle fusion | O89053 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | phagolysosome assembly | O89053 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | positive regulation of establishment of protein localization | Q9UQ03 Coronin-2B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | positive regulation of lamellipodium morphogenesis | Q9BR76 Coronin-1B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | positive regulation of lamellipodium morphogenesis | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | positive regulation of lamellipodium morphogenesis | Q9WUM4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | protein localization to cell leading edge | Q9BR76 Coronin-1B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | protein localization to cell leading edge | Q9WUM3 Coronin-1B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | regulation of actin polymerization or depolymerization | O89053 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | regulation of epithelial cell migration | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | regulation of epithelial cell migration | Q9WUM4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | regulation of fibroblast migration | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | regulation of glomerular filtration | Q8BH44 Coronin-2B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | regulation of release of sequestered calcium ion into cytosol | O89053 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | regulation of ruffle assembly | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | regulation of ruffle assembly | Q9WUM4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | regulation of substrate adhesion-dependent cell spreading | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | uropod organization | O89053 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Domain of unknown function DUF1899 | O89053 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Domain of unknown function DUF1899 | P57737 Coronin-7 | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Domain of unknown function DUF1899 | Q9BR76 Coronin-1B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Domain of unknown function DUF1899 | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Domain of unknown function DUF1899 | Q9UQ03 Coronin-2B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Domain of unknown function DUF1899 | Q9WUM3 Coronin-1B | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Domain of unknown function DUF1899 | Q9WUM4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Domain of unknown function DUF1899 | trait identifier | |
| DUF1899 (PF08953) | ProteinTraitsMech | Trimerisation motif | O89053 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Trimerisation motif | O89053 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Trimerisation motif | P31146 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Trimerisation motif | Q92176 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Trp-Asp (WD) repeats signature | P57737 Coronin-7 | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Domain of unknown function (DUF1899) | P31146 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Domain of unknown function (DUF1899) | P57737 Coronin-7 | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Domain of unknown function (DUF1899) | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Domain of unknown function (DUF1899) | trait identifier | |
| DUF1899 (PF08953) | ProteinTraitsMech | Type of WD40 repeat | P31146 Coronin-1A | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Type of WD40 repeat | P57737 Coronin-7 | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | Type of WD40 repeat | Q9ULV4 Coronin-1C | canonical example family classification |
| DUF1899 (PF08953) | ProteinTraitsMech | WD domain, G-beta repeat | P57737 Coronin-7 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.