DUFMech

All families / PF08953

PF08953: DUF1899

Domain of unknown function (DUF1899)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF08953: Domain of unknown function (DUF1899)
IPR015048: integrated entry for Domain of unknown function (DUF1899)

Source description

This set of domains is found in various eukaryotic proteins. Function is unknown.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

12 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O89053Coronin-1A
Mus musculus
461 aa; version 5
UniProt 2026_03
UNIPROT FETCH
12 sibling references
P31146Coronin-1A
Homo sapiens
461 aa; version 4
UniProt 2026_03
PTM REGISTRY MIRROR
4 sibling references
P57737Coronin-7
Homo sapiens
925 aa; version 2
UniProt 2026_03
UNIPROT FETCH
5 sibling references
Q06440Coronin-like protein
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
651 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q6QEF8Coronin-6
Homo sapiens
472 aa; version 2
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q8BH44Coronin-2B
Mus musculus
480 aa; version 2
UniProt 2026_03
UNIPROT FETCH
3 sibling references
Q92176Coronin-1A
Bos taurus
461 aa; version 3
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q9BR76Coronin-1B
Homo sapiens
489 aa; version 1
UniProt 2026_03
UNIPROT FETCH
5 sibling references
Q9ULV4Coronin-1C
Homo sapiens
474 aa; version 1
UniProt 2026_03
UNIPROT FETCH
14 sibling references
Q9UQ03Coronin-2B
Homo sapiens
480 aa; version 4
UniProt 2026_03
UNIPROT FETCH
4 sibling references

First 10 shown; the FASTA and family JSON contain all examples.

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
12,107
matches
13,193
proteomes
2,919
taxa
7,698
structures
11
alphafold models
10,516
domain architectures
235

Classification basis

short name matches duf; name says unknown function; description says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF1899 (PF08953)ProteinTraitsMechstereocilium tipO89053
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechmyosin heavy chain bindingO89053
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechtalin bindingQ8BH44
Coronin-2B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechtalin bindingQ9UQ03
Coronin-2B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechactin cortical patch assemblyQ9WUM4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechactin filament branchingQ9BR76
Coronin-1B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechactin filament branchingQ9WUM3
Coronin-1B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechactin filament debranchingQ06440
Coronin-like protein
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechactivation of GTPase activityQ9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechendosome fissionQ9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechendosome fissionQ9WUM4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechendosome membrane tubulationQ9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechendosome membrane tubulationQ9WUM4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnatural killer cell degranulationO89053
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnegative regulation of actin nucleationO89053
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnegative regulation of cellular component organizationQ6QEF8
Coronin-6
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnegative regulation of epithelial cell migrationQ9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnegative regulation of establishment of protein localizationQ8BH44
Coronin-2B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnegative regulation of establishment of protein localizationQ9UQ03
Coronin-2B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnegative regulation of lamellipodium morphogenesisQ9WUM3
Coronin-1B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnegative regulation of protein kinase activity by regulation of protein phosphorylationQ9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnegative regulation of protein kinase activity by regulation of protein phosphorylationQ9WUM4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnegative regulation of smooth muscle cell chemotaxisQ9BR76
Coronin-1B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnegative regulation of smooth muscle cell chemotaxisQ9WUM3
Coronin-1B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnegative regulation of substrate adhesion-dependent cell spreadingQ9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechnegative regulation of vesicle fusionO89053
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechphagolysosome assemblyO89053
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechpositive regulation of establishment of protein localizationQ9UQ03
Coronin-2B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechpositive regulation of lamellipodium morphogenesisQ9BR76
Coronin-1B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechpositive regulation of lamellipodium morphogenesisQ9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechpositive regulation of lamellipodium morphogenesisQ9WUM4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechprotein localization to cell leading edgeQ9BR76
Coronin-1B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechprotein localization to cell leading edgeQ9WUM3
Coronin-1B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechregulation of actin polymerization or depolymerizationO89053
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechregulation of epithelial cell migrationQ9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechregulation of epithelial cell migrationQ9WUM4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechregulation of fibroblast migrationQ9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechregulation of glomerular filtrationQ8BH44
Coronin-2B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechregulation of release of sequestered calcium ion into cytosolO89053
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechregulation of ruffle assemblyQ9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechregulation of ruffle assemblyQ9WUM4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechregulation of substrate adhesion-dependent cell spreadingQ9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechuropod organizationO89053
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechDomain of unknown function DUF1899O89053
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechDomain of unknown function DUF1899P57737
Coronin-7
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechDomain of unknown function DUF1899Q9BR76
Coronin-1B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechDomain of unknown function DUF1899Q9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechDomain of unknown function DUF1899Q9UQ03
Coronin-2B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechDomain of unknown function DUF1899Q9WUM3
Coronin-1B
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechDomain of unknown function DUF1899Q9WUM4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechDomain of unknown function DUF1899
trait identifier
DUF1899 (PF08953)ProteinTraitsMechTrimerisation motifO89053
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechTrimerisation motifO89053
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechTrimerisation motifP31146
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechTrimerisation motifQ92176
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechTrp-Asp (WD) repeats signatureP57737
Coronin-7
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechDomain of unknown function (DUF1899)P31146
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechDomain of unknown function (DUF1899)P57737
Coronin-7
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechDomain of unknown function (DUF1899)Q9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechDomain of unknown function (DUF1899)
trait identifier
DUF1899 (PF08953)ProteinTraitsMechType of WD40 repeatP31146
Coronin-1A
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechType of WD40 repeatP57737
Coronin-7
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechType of WD40 repeatQ9ULV4
Coronin-1C
canonical example family classification
DUF1899 (PF08953)ProteinTraitsMechWD domain, G-beta repeatP57737
Coronin-7
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF08953.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.