PF09430: EMC7_beta-sandw

ER membrane protein complex subunit 7, beta-sandwich domain

Curation status: SEEDED
Seed status: EX DUF
Characterization: UNSCORED

Grounding

PF09430: ER membrane protein complex subunit 7, beta-sandwich domain
IPR019008: integrated entry for ER membrane protein complex subunit 7, beta-sandwich domain

Source description

This is the beta-sandwich domain found in ER membrane protein complex subunit 7 (EMC7) [InterPro reference PUB00096682,InterPro reference PUB00096681], which is an integral membrane component of the EMC. EMC is widely conserved and involved in membrane protein biogenesis. It mediates the insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins in an energy-independent manner, both post-translational insertions of tail-anchored proteins and co-translational insertion of multipass membrane proteins [InterPro reference PUB00096679,InterPro reference PUB00096678]. This entry includes UPF0620 protein C83.10 from S. pombe, an orthologue of animal EMC7. This domain is also found in nodal modulators, which have been identified as part of a protein complex that participates in the nodal signalling pathway during vertebrate development [InterPro reference PUB00054165].

Evidence and references

InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
Frozen description source: InterPro/Pfam API

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

6 verified sequence examples. FASTA

UniProt	Protein / organism	Sequence	Provenance
A5PJA8	Endoplasmic reticulum membrane protein complex subunit 7 Bos taurus	241 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF09430
Q5TYV0	Endoplasmic reticulum membrane protein complex subunit 7 Danio rerio	237 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: Pfam:PF09430
Q8VY97	ER membrane protein complex subunit 7 homolog Arabidopsis thaliana	202 aa; version 1 UniProt 2026_03	UNIPROT FETCH 2 sibling references ProteinTraitsMech: InterPro:IPR019008 ProteinTraitsMech: InterPro:IPR013784
Q8WQG1	ER membrane protein complex subunit 7 homolog Caenorhabditis elegans	222 aa; version 1 UniProt 2026_03	UNIPROT FETCH 1 sibling references ProteinTraitsMech: InterPro:IPR019008
Q9EP72	Endoplasmic reticulum membrane protein complex subunit 7 Mus musculus	241 aa; version 1 UniProt 2026_03	UNIPROT FETCH 2 sibling references ProteinTraitsMech: InterPro:IPR019008 ProteinTraitsMech: InterPro:IPR013784
Q9NPA0	Endoplasmic reticulum membrane protein complex subunit 7 Homo sapiens	242 aa; version 1 UniProt 2026_03	PTM REGISTRY MIRROR 4 sibling references ProteinTraitsMech: InterPro:IPR019008 ProteinTraitsMech: Pfam:PF09430 ProteinTraitsMech: InterPro:IPR013784 ProteinTraitsMech: UniProtKB:Q9NPA0

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins: 3,924
matches: 3,930
proteomes: 3,079
taxa: 8,340
structures: 9
alphafold models: 3,381
domain architectures: 103

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF09430.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.