All families / PF09740
PF09740: DUF2043
Uncharacterized conserved protein (DUF2043)
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF09740: Uncharacterized conserved protein (DUF2043)
IPR049431: integrated entry for Uncharacterized conserved protein (DUF2043)
Source description
This is a 100 residue conserved region of a family of proteins found from fungi to humans. This region contains three conserved Cysteines and a motif of {CP}{y/l}{HG}.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
6 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| E7EXT2 | UV-stimulated scaffold protein A Danio rerio | 721 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| F1MX48 | UV-stimulated scaffold protein A Bos taurus | 685 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q23088 | UV-stimulated scaffold protein A homolog Caenorhabditis elegans | 594 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q2YD98 | UV-stimulated scaffold protein A Homo sapiens | 709 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q9D479 | UV-stimulated scaffold protein A Mus musculus | 717 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q9M358 | UV-stimulated scaffold protein A homolog Arabidopsis thaliana | 664 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 1,795
- matches
- 1,797
- proteomes
- 1,342
- taxa
- 4,255
- structures
- 11
- alphafold models
- 1,538
- domain architectures
- 25
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF2043 (PF09740) | ProteinTraitsMech | RNA polymerase inhibitor activity | Q2YD98 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | RNA polymerase inhibitor activity | Q9D479 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | UV-stimulated scaffold protein A, C-terminal domain | Q23088 UV-stimulated scaffold protein A homolog | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | UV-stimulated scaffold protein A, C-terminal domain | Q2YD98 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | UV-stimulated scaffold protein A, C-terminal domain | Q9D479 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | UV-stimulated scaffold protein A, C-terminal domain | Q9M358 UV-stimulated scaffold protein A homolog | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | UV-stimulated scaffold protein A, C-terminal domain | trait identifier | |
| DUF2043 (PF09740) | ProteinTraitsMech | Uncharacterized conserved protein (DUF2043) | E7EXT2 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | Uncharacterized conserved protein (DUF2043) | F1MX48 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | Uncharacterized conserved protein (DUF2043) | Q2YD98 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | Uncharacterized conserved protein (DUF2043) | trait identifier | |
| DUF2043 (PF09740) | ProteinTraitsMech | Zinc finger UVSSA-type profile | Q23088 UV-stimulated scaffold protein A homolog | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | Zinc finger UVSSA-type profile | Q2YD98 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | Zinc finger UVSSA-type profile | Q9D479 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | Zinc finger UVSSA-type profile | Q9M358 UV-stimulated scaffold protein A homolog | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | UV-stimulated scaffold protein A, N-terminal alpha-solenoid repeats | Q23088 UV-stimulated scaffold protein A homolog | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | UV-stimulated scaffold protein A, N-terminal alpha-solenoid repeats | Q2YD98 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | UV-stimulated scaffold protein A, N-terminal alpha-solenoid repeats | Q9D479 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | UV-stimulated scaffold protein A, N-terminal alpha-solenoid repeats | Q9M358 UV-stimulated scaffold protein A homolog | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | UVSSA N-terminal domain | E7EXT2 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | UVSSA N-terminal domain | F1MX48 UV-stimulated scaffold protein A | canonical example family classification |
| DUF2043 (PF09740) | ProteinTraitsMech | UVSSA N-terminal domain | Q2YD98 UV-stimulated scaffold protein A | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.