PF10223: Menorin_N

Menorin N-terminal domain

Curation status: SEEDED
Seed status: EX DUF
Characterization: UNSCORED

Grounding

PF10223: Menorin N-terminal domain
IPR019356: integrated entry for Menorin N-terminal domain

Source description

This entyr includes proteins FAM151A and FAM151B, the mammalian homologues of C. elegans menorin which is involved in generation of neurons and regulation of dendrite extension [InterPro reference PUB00100987,InterPro reference PUB00100988]. FAM151B has been shown to be essential for retinal function [InterPro reference PUB00100987]. Sequence analysis and the fact that these proteins have a TIM-barrel fold similar to that in phospholipase D and glycerophosphodiester phosphodiesterase (GDPD) families, indicate that they belong to PLC-like phosphodiesterase superfamily, although their substrates and function remain unknown. According to structure predictions, this domain is found at the N-terminal of menorin while in FAM151A is found twice and in FAM151B which is much shorter, it is the only domain present.

Evidence and references

InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
Frozen description source: InterPro/Pfam API

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

5 verified sequence examples. FASTA

UniProt	Protein / organism	Sequence	Provenance
D3YUE4	Protein FAM151B Mus musculus	279 aa; version 1 UniProt 2026_03	UNIPROT FETCH 2 sibling references ProteinTraitsMech: InterPro:IPR019356 ProteinTraitsMech: Pfam:PF10223
O45879	Menorin Caenorhabditis elegans	530 aa; version 2 UniProt 2026_03	PTM REGISTRY MIRROR 6 sibling references ProteinTraitsMech: GO:1903859 ProteinTraitsMech: InterPro:IPR057489 ProteinTraitsMech: InterPro:IPR019356 ProteinTraitsMech: Pfam:PF25161 ProteinTraitsMech: Pfam:PF10223 ProteinTraitsMech: UniProtKB:O45879
Q6UXP7	Protein FAM151B Homo sapiens	276 aa; version 2 UniProt 2026_03	UNIPROT FETCH 2 sibling references ProteinTraitsMech: InterPro:IPR019356 ProteinTraitsMech: Pfam:PF10223
Q8QZW3	Protein FAM151A Mus musculus	608 aa; version 1 UniProt 2026_03	UNIPROT FETCH 2 sibling references ProteinTraitsMech: InterPro:IPR019356 ProteinTraitsMech: Pfam:PF10223
Q8WW52	Protein FAM151A Homo sapiens	585 aa; version 2 UniProt 2026_03	UNIPROT FETCH 2 sibling references ProteinTraitsMech: InterPro:IPR019356 ProteinTraitsMech: Pfam:PF10223

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins: 2,267
matches: 2,741
proteomes: 1,273
taxa: 4,141
structures: 0
alphafold models: 1,940
domain architectures: 42

Classification basis

pfam previous unknown name

No scoring reasons supplied.

Related Mech records

This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.

No cross-Mech examples are present in the supplied snapshot.

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF10223.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.