All families / PF10240
PF10240: MABP
MABP domain
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF10240: MABP domain
IPR023341: integrated entry for MABP domain
Source description
This domain is found in the N-terminal region of MVB12 proteins, which are subunits of the ESCRT-I complex involved in multivesicular body formation. The MABP domain adopts a type-I beta-prism fold with internal three-fold symmetry, consisting of three homologous segments each forming a three-stranded beta-sheet. It is found in diverse proteins including vertebrate DENND4A/B/C, Drosophila Crag, and bacterial MACPF-like proteins. The domain is believed to function as a membrane-associated adaptor that links other domains to vesicular membranes during intracellular trafficking. Most eukaryotic versions contain conserved cysteine residues in the first and third subdomains [InterPro reference PUB00045017,InterPro reference PUB00054220].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
8 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A6H8H2 | DENN domain-containing protein 4C Mus musculus | 1906 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q5VZ89 | DENN domain-containing protein 4C Homo sapiens | 1909 aa; version 3 UniProt 2026_03 | PTM REGISTRY MIRROR2 sibling references |
| Q6KAU4 | Multivesicular body subunit 12B Mus musculus | 317 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q78HU3 | Multivesicular body subunit 12A Mus musculus | 271 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q7Z401 | C-myc promoter-binding protein Homo sapiens | 1863 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q96EY5 | Multivesicular body subunit 12A Homo sapiens | 273 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR11 sibling references
|
| Q9H7P6 | Multivesicular body subunit 12B Homo sapiens | 319 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR9 sibling references
|
| Q9W3D3 | DENN domain-containing protein Crag Drosophila melanogaster | 1671 aa; version 3 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 5,658
- matches
- 5,672
- proteomes
- 1,228
- taxa
- 4,000
- structures
- 2
- alphafold models
- 1,252
- domain architectures
- 65
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.