DUFMech

All families / PF11851

PF11851: DUF3371

Domain of unknown function (DUF3371)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF11851: Domain of unknown function (DUF3371)
IPR021802: integrated entry for Domain of unknown function (DUF3371)

Source description

This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

8 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O14948Transcription factor EC
Homo sapiens
347 aa; version 1
UniProt 2026_03
UNIPROT FETCH
3 sibling references
O75030Microphthalmia-associated transcription factor
Homo sapiens
526 aa; version 2
UniProt 2026_03
UNIPROT FETCH
6 sibling references
P19484Transcription factor EB
Homo sapiens
476 aa; version 3
UniProt 2026_03
UNIPROT FETCH
7 sibling references
P19532Transcription factor E3
Homo sapiens
575 aa; version 4
UniProt 2026_03
UNIPROT FETCH
5 sibling references
Q08874Microphthalmia-associated transcription factor
Mus musculus
526 aa; version 4
UniProt 2026_03
UNIPROT FETCH
5 sibling references
Q64092Transcription factor E3
Mus musculus
572 aa; version 2
UniProt 2026_03
UNIPROT FETCH
5 sibling references
Q9R210Transcription factor EB
Mus musculus
475 aa; version 2
UniProt 2026_03
UNIPROT FETCH
5 sibling references
Q9WTW4Transcription factor EC
Mus musculus
317 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
5,325
matches
5,354
proteomes
756
taxa
2,383
structures
3
alphafold models
4,758
domain architectures
17

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF3371 (PF11851)ProteinTraitsMechregulation of lysosome organizationP19484
Transcription factor EB
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechregulation of RNA biosynthetic processO75030
Microphthalmia-associated transcription factor
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechregulation of RNA biosynthetic processQ08874
Microphthalmia-associated transcription factor
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechbHLHzip_MITFO75030
Microphthalmia-associated transcription factor
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechbHLHzip_MITFQ08874
Microphthalmia-associated transcription factor
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechbHLHzip_MITFQ9WTW4
Transcription factor EC
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechbHLHzip_TFECO14948
Transcription factor EC
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechbHLHzip_TFEBP19484
Transcription factor EB
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechbHLHzip_TFEBQ9R210
Transcription factor EB
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechbHLHzip_TFE3P19532
Transcription factor E3
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechbHLHzip_TFE3Q64092
Transcription factor E3
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, C-terminalO14948
Transcription factor EC
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, C-terminalO75030
Microphthalmia-associated transcription factor
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, C-terminalP19484
Transcription factor EB
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, C-terminalP19532
Transcription factor E3
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, C-terminalQ08874
Microphthalmia-associated transcription factor
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, C-terminalQ64092
Transcription factor E3
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, C-terminalQ9R210
Transcription factor EB
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, C-terminalQ9WTW4
Transcription factor EC
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, C-terminal
trait identifier
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, N-terminalO75030
Microphthalmia-associated transcription factor
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, N-terminalP19484
Transcription factor EB
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, N-terminalP19532
Transcription factor E3
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, N-terminalQ08874
Microphthalmia-associated transcription factor
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, N-terminalQ64092
Transcription factor E3
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMiT/TFE transcription factors, N-terminalQ9R210
Transcription factor EB
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechTranscription factor E3, bHLHzip domainP19532
Transcription factor E3
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechTranscription factor E3, bHLHzip domainQ64092
Transcription factor E3
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechTranscription factor EB, bHLHzip domainP19484
Transcription factor EB
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechTranscription factor EB, bHLHzip domainQ9R210
Transcription factor EB
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechDomain of unknown function (DUF3371)O14948
Transcription factor EC
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechDomain of unknown function (DUF3371)O75030
Microphthalmia-associated transcription factor
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechDomain of unknown function (DUF3371)P19484
Transcription factor EB
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechDomain of unknown function (DUF3371)
trait identifier
DUF3371 (PF11851)ProteinTraitsMechMITF/TFEB/TFEC/TFE3 N-terminusO75030
Microphthalmia-associated transcription factor
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMITF/TFEB/TFEC/TFE3 N-terminusP19484
Transcription factor EB
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMITF/TFEB/TFEC/TFE3 N-terminusP19532
Transcription factor E3
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMITF/TFEB/TFEC/TFE3 N-terminusQ08874
Microphthalmia-associated transcription factor
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMITF/TFEB/TFEC/TFE3 N-terminusQ64092
Transcription factor E3
canonical example family classification
DUF3371 (PF11851)ProteinTraitsMechMITF/TFEB/TFEC/TFE3 N-terminusQ9R210
Transcription factor EB
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF11851.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.