All families / PF11864
PF11864: DUF3384
Domain of unknown function (DUF3384)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF11864: Domain of unknown function (DUF3384)
IPR024584: integrated entry for Domain of unknown function (DUF3384)
Source description
This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with PF02145 (Pfam entry).
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 4,026
- matches
- 4,140
- proteomes
- 2,365
- taxa
- 6,322
- structures
- 3
- alphafold models
- 399
- domain architectures
- 48
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF3384 (PF11864) | ProteinTraitsMech | TSC1-TSC2 complex | P49815 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | TSC1-TSC2 complex | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | 14-3-3 protein binding | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | phosphatase binding | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | anoikis | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | connective tissue replacement | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | excitatory chemical synaptic transmission | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | inhibitory chemical synaptic transmission | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | myofibroblast differentiation | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | negative regulation of axonogenesis | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | negative regulation of fibroblast proliferation | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | negative regulation of macroautophagy | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | negative regulation of mitophagy | P49815 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | negative regulation of pinocytosis | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | negative regulation of TOR signaling | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | negative regulation of TORC1 signaling | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | negative regulation of vascular endothelial cell proliferation | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | negative regulation of Wnt signaling pathway | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | positive regulation of fibroblast migration | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | positive regulation of translational initiation | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | protein transport into plasma membrane raft | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | proximal tubule development | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | regulation of insulin receptor signaling pathway | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | regulation of small GTPase mediated signal transduction | P49815 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | regulation of small GTPase mediated signal transduction | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | tissue remodeling | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Rap/Ran-GAP domain | P49815 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Rap/Ran-GAP domain | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Tuberin, N-terminal | P49815 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Tuberin, N-terminal | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Tuberin, N-terminal | trait identifier | |
| DUF3384 (PF11864) | ProteinTraitsMech | Tuberin-type domain | P49815 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Tuberin-type domain | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Rap/ran-GAP | P49815 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Rap/ran-GAP | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Domain of unknown function (DUF3384) | P49815 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Domain of unknown function (DUF3384) | P49816 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Domain of unknown function (DUF3384) | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Domain of unknown function (DUF3384) | trait identifier | |
| DUF3384 (PF11864) | ProteinTraitsMech | Tuberin | P49815 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Tuberin | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Rap/Ran-GAP superfamily | P49815 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Rap/Ran-GAP superfamily | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Rap GTPase activating proteins domain profile | P49815 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Rap GTPase activating proteins domain profile | Q61037 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Rap/Ran-GAP | P49815 Tuberin | canonical example family classification |
| DUF3384 (PF11864) | ProteinTraitsMech | Rap/Ran-GAP | Q61037 Tuberin | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.