DUFMech

All families / PF11864

PF11864: DUF3384

Domain of unknown function (DUF3384)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF11864: Domain of unknown function (DUF3384)
IPR024584: integrated entry for Domain of unknown function (DUF3384)

Source description

This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is typically between 422 to 486 amino acids in length. This domain is found associated with PF02145 (Pfam entry).

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

3 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
P49815Tuberin
Homo sapiens
1807 aa; version 2
UniProt 2026_03
PTM REGISTRY MIRROR
13 sibling references
P49816Tuberin
Rattus norvegicus
1809 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q61037Tuberin
Mus musculus
1814 aa; version 1
UniProt 2026_03
UNIPROT FETCH
32 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
4,026
matches
4,140
proteomes
2,365
taxa
6,322
structures
3
alphafold models
399
domain architectures
48

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF3384 (PF11864)ProteinTraitsMechTSC1-TSC2 complexP49815
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechTSC1-TSC2 complexQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMech14-3-3 protein bindingQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechphosphatase bindingQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechanoikisQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechconnective tissue replacementQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechexcitatory chemical synaptic transmissionQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechinhibitory chemical synaptic transmissionQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechmyofibroblast differentiationQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechnegative regulation of axonogenesisQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechnegative regulation of fibroblast proliferationQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechnegative regulation of macroautophagyQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechnegative regulation of mitophagyP49815
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechnegative regulation of pinocytosisQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechnegative regulation of TOR signalingQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechnegative regulation of TORC1 signalingQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechnegative regulation of vascular endothelial cell proliferationQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechnegative regulation of Wnt signaling pathwayQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechpositive regulation of fibroblast migrationQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechpositive regulation of translational initiationQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechprotein transport into plasma membrane raftQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechproximal tubule developmentQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechregulation of insulin receptor signaling pathwayQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechregulation of small GTPase mediated signal transductionP49815
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechregulation of small GTPase mediated signal transductionQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechtissue remodelingQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechRap/Ran-GAP domainP49815
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechRap/Ran-GAP domainQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechTuberin, N-terminalP49815
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechTuberin, N-terminalQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechTuberin, N-terminal
trait identifier
DUF3384 (PF11864)ProteinTraitsMechTuberin-type domainP49815
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechTuberin-type domainQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechRap/ran-GAPP49815
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechRap/ran-GAPQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechDomain of unknown function (DUF3384)P49815
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechDomain of unknown function (DUF3384)P49816
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechDomain of unknown function (DUF3384)Q61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechDomain of unknown function (DUF3384)
trait identifier
DUF3384 (PF11864)ProteinTraitsMechTuberinP49815
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechTuberinQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechRap/Ran-GAP superfamilyP49815
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechRap/Ran-GAP superfamilyQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechRap GTPase activating proteins domain profileP49815
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechRap GTPase activating proteins domain profileQ61037
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechRap/Ran-GAPP49815
Tuberin
canonical example family classification
DUF3384 (PF11864)ProteinTraitsMechRap/Ran-GAPQ61037
Tuberin
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF11864.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.