All families / PF12012
PF12012: DUF3504
Domain of unknown function (DUF3504)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF12012: Domain of unknown function (DUF3504)
IPR021893: integrated entry for Domain of unknown function (DUF3504)
Source description
This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
10 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A2A791 | Zinc finger MYM-type protein 4 Mus musculus | 1549 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q14202 | Zinc finger MYM-type protein 3 Homo sapiens | 1370 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q2TAL8 | Transcriptional regulator QRICH1 Homo sapiens | 776 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q3UA37 | Transcriptional regulator QRICH1 Mus musculus | 777 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q5VZL5 | Zinc finger MYM-type protein 4 Homo sapiens | 1548 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q8C4P0 | Uncharacterized protein KIAA1958 homolog Mus musculus | 716 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8N8K9 | Uncharacterized protein KIAA1958 Homo sapiens | 716 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q9CU65 | Zinc finger MYM-type protein 2 Mus musculus | 1376 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| Q9JLM4 | Zinc finger MYM-type protein 3 Mus musculus | 1370 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9UBW7 | Zinc finger MYM-type protein 2 Homo sapiens | 1377 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 7,930
- matches
- 7,999
- proteomes
- 1,139
- taxa
- 3,772
- structures
- 2
- alphafold models
- 4,132
- domain architectures
- 222
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF3504 (PF12012) | ProteinTraitsMech | CARD | Q2TAL8 Transcriptional regulator QRICH1 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | CARD | Q3UA37 Transcriptional regulator QRICH1 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1-like domain | A2A791 Zinc finger MYM-type protein 4 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1-like domain | Q14202 Zinc finger MYM-type protein 3 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1-like domain | Q2TAL8 Transcriptional regulator QRICH1 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1-like domain | Q3UA37 Transcriptional regulator QRICH1 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1-like domain | Q5VZL5 Zinc finger MYM-type protein 4 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1-like domain | Q9CU65 Zinc finger MYM-type protein 2 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1-like domain | Q9JLM4 Zinc finger MYM-type protein 3 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1-like domain | Q9UBW7 Zinc finger MYM-type protein 2 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | TRASH domain | Q9UBW7 Zinc finger MYM-type protein 2 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | Zinc finger, MYM-type | Q9CU65 Zinc finger MYM-type protein 2 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | Zinc finger, MYM-type | Q9JLM4 Zinc finger MYM-type protein 3 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | Zinc finger, MYM-type | Q9UBW7 Zinc finger MYM-type protein 2 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | ZMYM2-like/QRICH1, C-terminal domain | Q14202 Zinc finger MYM-type protein 3 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | ZMYM2-like/QRICH1, C-terminal domain | Q2TAL8 Transcriptional regulator QRICH1 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | ZMYM2-like/QRICH1, C-terminal domain | Q3UA37 Transcriptional regulator QRICH1 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | ZMYM2-like/QRICH1, C-terminal domain | Q8C4P0 Uncharacterized protein KIAA1958 homolog | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | ZMYM2-like/QRICH1, C-terminal domain | Q8N8K9 Uncharacterized protein KIAA1958 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | ZMYM2-like/QRICH1, C-terminal domain | Q9CU65 Zinc finger MYM-type protein 2 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | ZMYM2-like/QRICH1, C-terminal domain | Q9JLM4 Zinc finger MYM-type protein 3 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | ZMYM2-like/QRICH1, C-terminal domain | Q9UBW7 Zinc finger MYM-type protein 2 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | ZMYM2-like/QRICH1, C-terminal domain | trait identifier | |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1 domain | A2A791 Zinc finger MYM-type protein 4 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1 domain | Q14202 Zinc finger MYM-type protein 3 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1 domain | Q2TAL8 Transcriptional regulator QRICH1 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1 domain | Q3UA37 Transcriptional regulator QRICH1 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1 domain | Q5VZL5 Zinc finger MYM-type protein 4 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1 domain | Q9CU65 Zinc finger MYM-type protein 2 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1 domain | Q9JLM4 Zinc finger MYM-type protein 3 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | QRICH1 domain | Q9UBW7 Zinc finger MYM-type protein 2 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | Zinc finger MYM-type protein 4-like, TRASH domain | A2A791 Zinc finger MYM-type protein 4 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | Zinc finger MYM-type protein 4-like, TRASH domain | Q5VZL5 Zinc finger MYM-type protein 4 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | MYM-type Zinc finger with FCS sequence motif | Q9CU65 Zinc finger MYM-type protein 2 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | MYM-type Zinc finger with FCS sequence motif | Q9JLM4 Zinc finger MYM-type protein 3 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | MYM-type Zinc finger with FCS sequence motif | Q9UBW7 Zinc finger MYM-type protein 2 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | Domain of unknown function (DUF3504) | Q14202 Zinc finger MYM-type protein 3 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | Domain of unknown function (DUF3504) | Q2TAL8 Transcriptional regulator QRICH1 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | Domain of unknown function (DUF3504) | Q5VZL5 Zinc finger MYM-type protein 4 | canonical example family classification |
| DUF3504 (PF12012) | ProteinTraitsMech | Domain of unknown function (DUF3504) | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.