All families / PF12534
PF12534: Pannexin_like
Pannexin-like TM region of LRRC8
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF12534: Pannexin-like TM region of LRRC8
IPR021040: integrated entry for Pannexin-like TM region of LRRC8
Source description
Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with PF00560 (Pfam entry) [InterPro reference PUB00075689].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
9 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q66JT1 | Volume-regulated anion channel subunit LRRC8E Mus musculus | 795 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q6NSJ5 | Volume-regulated anion channel subunit LRRC8E Homo sapiens | 796 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q6P9F7 | Volume-regulated anion channel subunit LRRC8B Homo sapiens | 803 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q7L1W4 | Volume-regulated anion channel subunit LRRC8D Homo sapiens | 858 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q80WG5 | Volume-regulated anion channel subunit LRRC8A Mus musculus | 810 aa; version 1 UniProt 2026_03 | UNIPROT FETCH10 sibling references
|
| Q8BGR2 | Volume-regulated anion channel subunit LRRC8D Mus musculus | 859 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q8IWT6 | Volume-regulated anion channel subunit LRRC8A Homo sapiens | 810 aa; version 1 UniProt 2026_03 | UNIPROT FETCH10 sibling references
|
| Q8R502 | Volume-regulated anion channel subunit LRRC8C Mus musculus | 803 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q8TDW0 | Volume-regulated anion channel subunit LRRC8C Homo sapiens | 803 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 4,357
- matches
- 4,478
- proteomes
- 773
- taxa
- 2,372
- structures
- 49
- alphafold models
- 3,834
- domain architectures
- 114
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.