All families / PF12548
PF12548: DUF3740
Sulfatase protein
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF12548: Sulfatase protein
IPR024609: integrated entry for Sulfatase protein
Source description
This domain family is found in eukaryotes, and is typically between 144 and 173 amino acids in length. The family is found in association with PF00884 (Pfam entry).
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
5 verified sequence examples. FASTA
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 3,855
- matches
- 4,724
- proteomes
- 1,064
- taxa
- 3,500
- structures
- 0
- alphafold models
- 3,331
- domain architectures
- 20
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfuric ester hydrolases | Q9VEX0 Extracellular sulfatase SULF-1 homolog | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | arylsulfatase activity | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | arylsulfatase activity | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | arylsulfatase activity | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | arylsulfatase activity | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | N-acetylglucosamine-6-sulfatase activity | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | N-acetylglucosamine-6-sulfatase activity | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | N-acetylglucosamine-6-sulfatase activity | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | N-acetylglucosamine-6-sulfatase activity | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | N-acetylglucosamine-6-sulfatase activity | Q9VEX0 Extracellular sulfatase SULF-1 homolog | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | esophagus smooth muscle contraction | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | esophagus smooth muscle contraction | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | esophagus smooth muscle contraction | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | esophagus smooth muscle contraction | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | glial cell-derived neurotrophic factor receptor signaling pathway | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | glial cell-derived neurotrophic factor receptor signaling pathway | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | glial cell-derived neurotrophic factor receptor signaling pathway | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | glial cell-derived neurotrophic factor receptor signaling pathway | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | glomerular basement membrane development | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | glomerular basement membrane development | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | glomerular basement membrane development | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | glomerular basement membrane development | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | heparan sulfate proteoglycan catabolic process | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | heparan sulfate proteoglycan catabolic process | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | heparan sulfate proteoglycan catabolic process | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | heparan sulfate proteoglycan metabolic process | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | heparan sulfate proteoglycan metabolic process | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | heparan sulfate proteoglycan metabolic process | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | heparan sulfate proteoglycan metabolic process | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | innervation | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | innervation | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | limb joint morphogenesis | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | negative regulation of prostatic bud formation | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | negative regulation of prostatic bud formation | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | positive regulation of endothelin production | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | positive regulation of endothelin production | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | regulation of fibroblast growth factor receptor signaling pathway | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | regulation of fibroblast growth factor receptor signaling pathway | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | regulation of hepatocyte proliferation | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | sulfur compound metabolic process | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | sulfur compound metabolic process | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | synaptic target inhibition | Q9VEX0 Extracellular sulfatase SULF-1 homolog | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase, conserved site | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase, conserved site | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase, conserved site | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase, conserved site | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase, conserved site | Q9VEX0 Extracellular sulfatase SULF-1 homolog | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | G6S | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | G6S | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | G6S | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | G6S | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | G6S | Q9VEX0 Extracellular sulfatase SULF-1 homolog | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Extracellular sulfatase, C-terminal | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Extracellular sulfatase, C-terminal | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Extracellular sulfatase, C-terminal | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Extracellular sulfatase, C-terminal | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Extracellular sulfatase, C-terminal | Q9VEX0 Extracellular sulfatase SULF-1 homolog | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Extracellular sulfatase, C-terminal | trait identifier | |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase, N-terminal | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase, N-terminal | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase, N-terminal | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase, N-terminal | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase protein | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase protein | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase protein | Q9VEX0 Extracellular sulfatase SULF-1 homolog | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase protein | trait identifier | |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Sulfatase | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Alkaline Phosphatase, subunit A | Q8CFG0 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Alkaline Phosphatase, subunit A | Q8IWU5 Extracellular sulfatase Sulf-2 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Alkaline Phosphatase, subunit A | Q8IWU6 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Alkaline Phosphatase, subunit A | Q8K007 Extracellular sulfatase Sulf-1 | canonical example family classification |
| DUF3740 (PF12548) | ProteinTraitsMech | Alkaline Phosphatase, subunit A | Q9VEX0 Extracellular sulfatase SULF-1 homolog | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.