DUFMech

All families / PF12548

PF12548: DUF3740

Sulfatase protein

Curation status
SEEDED
Seed status
KNOWN HISTORICAL DUF
Characterization
UNSCORED

Grounding

PF12548: Sulfatase protein
IPR024609: integrated entry for Sulfatase protein

Source description

This domain family is found in eukaryotes, and is typically between 144 and 173 amino acids in length. The family is found in association with PF00884 (Pfam entry).

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

5 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
Q8CFG0Extracellular sulfatase Sulf-2
Mus musculus
875 aa; version 2
UniProt 2026_03
UNIPROT FETCH
15 sibling references
Q8IWU5Extracellular sulfatase Sulf-2
Homo sapiens
870 aa; version 1
UniProt 2026_03
UNIPROT FETCH
15 sibling references
Q8IWU6Extracellular sulfatase Sulf-1
Homo sapiens
871 aa; version 1
UniProt 2026_03
UNIPROT FETCH
17 sibling references
Q8K007Extracellular sulfatase Sulf-1
Mus musculus
870 aa; version 1
UniProt 2026_03
UNIPROT FETCH
18 sibling references
Q9VEX0Extracellular sulfatase SULF-1 homolog
Drosophila melanogaster
1114 aa; version 1
UniProt 2026_03
UNIPROT FETCH
8 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
3,855
matches
4,724
proteomes
1,064
taxa
3,500
structures
0
alphafold models
3,331
domain architectures
20

Classification basis

short name matches duf

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF3740 (PF12548)ProteinTraitsMechSulfuric ester hydrolasesQ9VEX0
Extracellular sulfatase SULF-1 homolog
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMecharylsulfatase activityQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMecharylsulfatase activityQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMecharylsulfatase activityQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMecharylsulfatase activityQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechN-acetylglucosamine-6-sulfatase activityQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechN-acetylglucosamine-6-sulfatase activityQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechN-acetylglucosamine-6-sulfatase activityQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechN-acetylglucosamine-6-sulfatase activityQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechN-acetylglucosamine-6-sulfatase activityQ9VEX0
Extracellular sulfatase SULF-1 homolog
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechesophagus smooth muscle contractionQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechesophagus smooth muscle contractionQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechesophagus smooth muscle contractionQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechesophagus smooth muscle contractionQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechglial cell-derived neurotrophic factor receptor signaling pathwayQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechglial cell-derived neurotrophic factor receptor signaling pathwayQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechglial cell-derived neurotrophic factor receptor signaling pathwayQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechglial cell-derived neurotrophic factor receptor signaling pathwayQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechglomerular basement membrane developmentQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechglomerular basement membrane developmentQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechglomerular basement membrane developmentQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechglomerular basement membrane developmentQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechheparan sulfate proteoglycan catabolic processQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechheparan sulfate proteoglycan catabolic processQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechheparan sulfate proteoglycan catabolic processQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechheparan sulfate proteoglycan metabolic processQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechheparan sulfate proteoglycan metabolic processQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechheparan sulfate proteoglycan metabolic processQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechheparan sulfate proteoglycan metabolic processQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechinnervationQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechinnervationQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechlimb joint morphogenesisQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechnegative regulation of prostatic bud formationQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechnegative regulation of prostatic bud formationQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechpositive regulation of endothelin productionQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechpositive regulation of endothelin productionQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechregulation of fibroblast growth factor receptor signaling pathwayQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechregulation of fibroblast growth factor receptor signaling pathwayQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechregulation of hepatocyte proliferationQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechsulfur compound metabolic processQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechsulfur compound metabolic processQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechsynaptic target inhibitionQ9VEX0
Extracellular sulfatase SULF-1 homolog
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfatase, conserved siteQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfatase, conserved siteQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfatase, conserved siteQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfatase, conserved siteQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfatase, conserved siteQ9VEX0
Extracellular sulfatase SULF-1 homolog
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechG6SQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechG6SQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechG6SQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechG6SQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechG6SQ9VEX0
Extracellular sulfatase SULF-1 homolog
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechExtracellular sulfatase, C-terminalQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechExtracellular sulfatase, C-terminalQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechExtracellular sulfatase, C-terminalQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechExtracellular sulfatase, C-terminalQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechExtracellular sulfatase, C-terminalQ9VEX0
Extracellular sulfatase SULF-1 homolog
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechExtracellular sulfatase, C-terminal
trait identifier
DUF3740 (PF12548)ProteinTraitsMechSulfatase, N-terminalQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfatase, N-terminalQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfatase, N-terminalQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfatase, N-terminalQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfatase proteinQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfatase proteinQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfatase proteinQ9VEX0
Extracellular sulfatase SULF-1 homolog
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfatase protein
trait identifier
DUF3740 (PF12548)ProteinTraitsMechSulfataseQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfataseQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfataseQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechSulfataseQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechAlkaline Phosphatase, subunit AQ8CFG0
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechAlkaline Phosphatase, subunit AQ8IWU5
Extracellular sulfatase Sulf-2
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechAlkaline Phosphatase, subunit AQ8IWU6
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechAlkaline Phosphatase, subunit AQ8K007
Extracellular sulfatase Sulf-1
canonical example family classification
DUF3740 (PF12548)ProteinTraitsMechAlkaline Phosphatase, subunit AQ9VEX0
Extracellular sulfatase SULF-1 homolog
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF12548.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.