All families / PF12825
PF12825: DUF3818
Domain of unknown function in PX-proteins (DUF3818)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF12825: Domain of unknown function in PX-proteins (DUF3818)
IPR024554: integrated entry for Domain of unknown function in PX-proteins (DUF3818)
Source description
This domain is found on proteins carrying a PX domain. Its function is unknown.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O74521 | Uncharacterized protein C663.15c Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 678 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q06839 | PX domain-containing protein LEC1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 1073 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q9Y7N9 | PX domain-containing protein C1450.12 Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 821 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 2,324
- matches
- 2,741
- proteomes
- 1,416
- taxa
- 3,022
- structures
- 0
- alphafold models
- 1,748
- domain architectures
- 46
Classification basis
short name matches duf; name says unknown function; description says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF3818 (PF12825) | ProteinTraitsMech | PX_UP2_fungi | Q06839 PX domain-containing protein LEC1 | canonical example family classification |
| DUF3818 (PF12825) | ProteinTraitsMech | PX-associated domain | Q06839 PX domain-containing protein LEC1 | canonical example family classification |
| DUF3818 (PF12825) | ProteinTraitsMech | PX domain-containing protein LEC1-like, C-terminal | Q06839 PX domain-containing protein LEC1 | canonical example family classification |
| DUF3818 (PF12825) | ProteinTraitsMech | PX domain-containing protein LEC1-like, C-terminal | trait identifier | |
| DUF3818 (PF12825) | ProteinTraitsMech | Domain of unknown function in PX-proteins (DUF3818) | O74521 Uncharacterized protein C663.15c | canonical example family classification |
| DUF3818 (PF12825) | ProteinTraitsMech | Domain of unknown function in PX-proteins (DUF3818) | Q06839 PX domain-containing protein LEC1 | canonical example family classification |
| DUF3818 (PF12825) | ProteinTraitsMech | Domain of unknown function in PX-proteins (DUF3818) | Q9Y7N9 PX domain-containing protein C1450.12 | canonical example family classification |
| DUF3818 (PF12825) | ProteinTraitsMech | Domain of unknown function in PX-proteins (DUF3818) | trait identifier | |
| DUF3818 (PF12825) | ProteinTraitsMech | PX-associated | Q06839 PX domain-containing protein LEC1 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.