All families / PF12842
PF12842: DUF3819
CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF12842: CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819
IPR024557: integrated entry for CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819
Source description
This is an uncharacterised domain that is found on the CCR4-Not complex component Not1. Not1 is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID [InterPro reference PUB00010586].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
6 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A1A5H6 | CCR4-NOT transcription complex subunit 1 Danio rerio | 2374 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| A5YKK6 | CCR4-NOT transcription complex subunit 1 Homo sapiens | 2376 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| P25655 | General negative regulator of transcription subunit 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 2108 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| P87112 | General negative regulator of transcription subunit 1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 2100 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q20937 | CCR4-NOT transcription complex subunit let-711 Caenorhabditis elegans | 2641 aa; version 3 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q6ZQ08 | CCR4-NOT transcription complex subunit 1 Mus musculus | 2375 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 5,334
- matches
- 5,351
- proteomes
- 3,046
- taxa
- 8,104
- structures
- 7
- alphafold models
- 297
- domain architectures
- 202
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1, domain 4 | trait identifier | |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819 | A5YKK6 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819 | P25655 General negative regulator of transcription subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819 | Q6ZQ08 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819 | trait identifier | |
| DUF3819 (PF12842) | ProteinTraitsMech | Cnot1 ARM repeat | P25655 General negative regulator of transcription subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | Cnot1 ARM repeat | P87112 General negative regulator of transcription subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | Cnot1 ARM repeat | Q20937 CCR4-NOT transcription complex subunit let-711 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1, N-terminal domain | A1A5H6 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1, N-terminal domain | A5YKK6 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1, N-terminal domain | Q6ZQ08 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1 CAF1-binding domain | A5YKK6 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1 CAF1-binding domain | P25655 General negative regulator of transcription subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1 CAF1-binding domain | Q6ZQ08 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1 HEAT repeat | P25655 General negative regulator of transcription subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1 HEAT repeat | A5YKK6 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1 HEAT repeat | P25655 General negative regulator of transcription subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1 HEAT repeat | Q6ZQ08 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1 TTP binding domain | A5YKK6 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1 TTP binding domain | P25655 General negative regulator of transcription subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1 TTP binding domain | Q6ZQ08 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1, NOT1_connector | A1A5H6 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1, NOT1_connector | A5YKK6 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-NOT transcription complex subunit 1, NOT1_connector | Q6ZQ08 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-Not complex component, Not1 | A5YKK6 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-Not complex component, Not1 | P25655 General negative regulator of transcription subunit 1 | canonical example family classification |
| DUF3819 (PF12842) | ProteinTraitsMech | CCR4-Not complex component, Not1 | Q6ZQ08 CCR4-NOT transcription complex subunit 1 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.