DUFMech

All families / PF12842

PF12842: DUF3819

CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF12842: CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819
IPR024557: integrated entry for CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819

Source description

This is an uncharacterised domain that is found on the CCR4-Not complex component Not1. Not1 is a global regulator of transcription that affects genes positively and negatively and is thought to regulate transcription factor TFIID [InterPro reference PUB00010586].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

6 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
A1A5H6CCR4-NOT transcription complex subunit 1
Danio rerio
2374 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references
A5YKK6CCR4-NOT transcription complex subunit 1
Homo sapiens
2376 aa; version 2
UniProt 2026_03
PTM REGISTRY MIRROR
8 sibling references
P25655General negative regulator of transcription subunit 1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
2108 aa; version 3
UniProt 2026_03
UNIPROT FETCH
7 sibling references
P87112General negative regulator of transcription subunit 1
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
2100 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q20937CCR4-NOT transcription complex subunit let-711
Caenorhabditis elegans
2641 aa; version 3
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q6ZQ08CCR4-NOT transcription complex subunit 1
Mus musculus
2375 aa; version 2
UniProt 2026_03
UNIPROT FETCH
7 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
5,334
matches
5,351
proteomes
3,046
taxa
8,104
structures
7
alphafold models
297
domain architectures
202

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1, domain 4
trait identifier
DUF3819 (PF12842)ProteinTraitsMechCCR4-Not complex, Not1 subunit, domain of unknown function DUF3819A5YKK6
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-Not complex, Not1 subunit, domain of unknown function DUF3819P25655
General negative regulator of transcription subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-Not complex, Not1 subunit, domain of unknown function DUF3819Q6ZQ08
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-Not complex, Not1 subunit, domain of unknown function DUF3819
trait identifier
DUF3819 (PF12842)ProteinTraitsMechCnot1 ARM repeatP25655
General negative regulator of transcription subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCnot1 ARM repeatP87112
General negative regulator of transcription subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCnot1 ARM repeatQ20937
CCR4-NOT transcription complex subunit let-711
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1, N-terminal domainA1A5H6
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1, N-terminal domainA5YKK6
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1, N-terminal domainQ6ZQ08
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1 CAF1-binding domainA5YKK6
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1 CAF1-binding domainP25655
General negative regulator of transcription subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1 CAF1-binding domainQ6ZQ08
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1 HEAT repeatP25655
General negative regulator of transcription subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1 HEAT repeatA5YKK6
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1 HEAT repeatP25655
General negative regulator of transcription subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1 HEAT repeatQ6ZQ08
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1 TTP binding domainA5YKK6
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1 TTP binding domainP25655
General negative regulator of transcription subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1 TTP binding domainQ6ZQ08
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1, NOT1_connectorA1A5H6
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1, NOT1_connectorA5YKK6
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-NOT transcription complex subunit 1, NOT1_connectorQ6ZQ08
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-Not complex component, Not1A5YKK6
CCR4-NOT transcription complex subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-Not complex component, Not1P25655
General negative regulator of transcription subunit 1
canonical example family classification
DUF3819 (PF12842)ProteinTraitsMechCCR4-Not complex component, Not1Q6ZQ08
CCR4-NOT transcription complex subunit 1
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF12842.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.