All families / PF12941
PF12941: HCV_NS5a_C
HCV NS5a protein C-terminal region
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF12941: HCV NS5a protein C-terminal region
IPR024350: integrated entry for HCV NS5a protein C-terminal region
Source description
This is a family of proteins found in the hepatitis C virus. This family contains the C-terminal region of the NS5A protein. CC The molecular function of the non-structural 5a protein is uncertain. The NS5a protein is phosphorylated when expressed in mammalian cells. It is thought to interact with the ds RNA dependent (interferon inducible) kinase PKR, P19525 (UniProtKB protein).
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
15 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A8QPD9 | Genome polyprotein Hepatitis C virus genotype 7a (isolate QC69) | 3013 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| O39927 | Genome polyprotein Hepatitis C virus genotype 6a (isolate EUHK2) | 3018 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| O39928 | Genome polyprotein Hepatitis C virus genotype 5a (isolate EUH1480) | 3014 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| O39929 | Genome polyprotein Hepatitis C virus genotype 4a (isolate ED43) | 3008 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| O91936 | Genome polyprotein Hepatitis C virus genotype 5a (isolate SA13) | 3014 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| O92529 | Genome polyprotein Hepatitis C virus genotype 6b (isolate Th580) | 3019 aa; version 3 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| O92530 | Genome polyprotein Hepatitis C virus genotype 6d (isolate VN235) | 3013 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| O92531 | Genome polyprotein Hepatitis C virus genotype 6k (isolate VN405) | 3016 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| P26662 | Genome polyprotein Hepatitis C virus genotype 1b (isolate Japanese) | 3010 aa; version 3 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P26663 | Genome polyprotein Hepatitis C virus genotype 1b (isolate BK) | 3010 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
First 10 shown; the FASTA and family JSON contain all examples.
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 2,466
- matches
- 2,488
- proteomes
- 13
- taxa
- 165
- structures
- 1
- alphafold models
- 25
- domain architectures
- 27
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.