DUFMech

All families / PF13271

PF13271: DUF4062

Domain of unknown function (DUF4062)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF13271: Domain of unknown function (DUF4062)
IPR025139: integrated entry for Domain of unknown function (DUF4062)

Source description

This presumed domain is functionally uncharacterised. This domain family is found in bacteria, archaea and eukaryotes. This domain shows structural similarity to TIR domains. This domain is found within the TEP1 (Telomerase protein component 1) protein.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

3 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O08653Telomerase protein component 1
Rattus norvegicus
2629 aa; version 1
UniProt 2026_03
UNIPROT FETCH
4 sibling references
P97499Telomerase protein component 1
Mus musculus
2629 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
6 sibling references
Q99973Telomerase protein component 1
Homo sapiens
2627 aa; version 2
UniProt 2026_03
PTM REGISTRY MIRROR
6 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
4,653
matches
4,656
proteomes
2,809
taxa
6,452
structures
4
alphafold models
1,957
domain architectures
764

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF4062 (PF13271)ProteinTraitsMechDomain of unknown function DUF4062
trait identifier
DUF4062 (PF13271)ProteinTraitsMechDomain of unknown function (DUF4062)O08653
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechDomain of unknown function (DUF4062)P97499
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechDomain of unknown function (DUF4062)Q99973
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechDomain of unknown function (DUF4062)
trait identifier
DUF4062 (PF13271)ProteinTraitsMechDomain of unknown function (DUF5920)O08653
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechDomain of unknown function (DUF5920)P97499
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechDomain of unknown function (DUF5920)Q99973
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechTEP-1 second beta-propellerO08653
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechTEP-1 second beta-propellerP97499
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechTEP-1 second beta-propellerQ99973
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechTEP-1 C-terminal beta-propellerO08653
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechTEP-1 C-terminal beta-propellerP97499
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechTEP-1 C-terminal beta-propellerQ99973
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechTROVE domainP97499
Telomerase protein component 1
canonical example family classification
DUF4062 (PF13271)ProteinTraitsMechTROVE domainQ99973
Telomerase protein component 1
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF13271.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.