DUFMech

All families / PF13322

PF13322: DUF4092

Domain of unknown function (DUF4092)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF13322: Domain of unknown function (DUF4092)
IPR025385: integrated entry for Domain of unknown function (DUF4092)

Source description

This family is found in Proteobacteria. The function is not known.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

3 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
A5F372Accessory colonization factor AcfD
Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
1520 aa; version 2
UniProt 2026_03
UNIPROT FETCH
2 sibling references
E3PJ90Putative lipoprotein YghJ
Escherichia coli O78:H11 (strain H10407 / ETEC)
1519 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references
P0CK95Putative lipoprotein AcfD homolog
Escherichia coli (strain K12)
1520 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
15 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
90
matches
91
proteomes
76
taxa
147
structures
0
alphafold models
5
domain architectures
4

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF4092 (PF13322)ProteinTraitsMechlipoprotein metalloprotease SslEP0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechSslE/AcfD family lipoprotein zinc metalloproteaseP0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechAcfD, middle domainP0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechAcfD, middle domain
trait identifier
DUF4092 (PF13322)ProteinTraitsMechM60-like domain, N-terminalP0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechPeptidase family M60 domainP0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechAcfD helical domainA5F372
Accessory colonization factor AcfD
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechAcfD helical domainE3PJ90
Putative lipoprotein YghJ
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechAcfD helical domainP0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechN-terminal domain of M60-like peptidasesP0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechPeptidase M60, enhancin and enhancin-likeP0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechDomain of unknown function (DUF4092)A5F372
Accessory colonization factor AcfD
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechDomain of unknown function (DUF4092)E3PJ90
Putative lipoprotein YghJ
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechDomain of unknown function (DUF4092)P0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechDomain of unknown function (DUF4092)
trait identifier
DUF4092 (PF13322)ProteinTraitsMechPeptidase M60, enhancin-like domain 3P0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechPeptidase family M60 domain profileP0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechPeptidase M60, enhancin-like domain 1P0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechPeptidase M60, enhancin-like domain 2P0CK95
Putative lipoprotein AcfD homolog
canonical example family classification
DUF4092 (PF13322)ProteinTraitsMechPeptidase M60, enhancin-like domain 3P0CK95
Putative lipoprotein AcfD homolog
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF13322.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.