DUFMech

All families / PF13331

PF13331: DUF4093

Domain of unknown function (DUF4093)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF13331: Domain of unknown function (DUF4093)
IPR025156: integrated entry for Domain of unknown function (DUF4093)

Source description

This domain lies at the C-terminus of primase proteins carrying the TOPRIM, PF01751 (Pfam entry), domain. The exact function of the domain is not known.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

3 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
P37547Ribonuclease M5
Bacillus subtilis (strain 168)
186 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
10 sibling references
P47303Ribonuclease M5
Mycoplasmoides genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
178 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
P75045Ribonuclease M5
Mycoplasmoides pneumoniae (strain ATCC 29342 / M129 / Subtype 1)
178 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
2,887
matches
2,887
proteomes
2,873
taxa
4,158
structures
2
alphafold models
1,897
domain architectures
10

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF4093 (PF13331)ProteinTraitsMechribonuclease M5 activityP37547
Ribonuclease M5
canonical example family classification
DUF4093 (PF13331)ProteinTraitsMechribonuclease M5P37547
Ribonuclease M5
canonical example family classification
DUF4093 (PF13331)ProteinTraitsMechTOPRIM_RNase_M5_likeP37547
Ribonuclease M5
canonical example family classification
DUF4093 (PF13331)ProteinTraitsMechRibonuclease M5, C-terminal domainP37547
Ribonuclease M5
canonical example family classification
DUF4093 (PF13331)ProteinTraitsMechRibonuclease M5, C-terminal domain
trait identifier
DUF4093 (PF13331)ProteinTraitsMechRibonuclease M5-like, TOPRIM domainP37547
Ribonuclease M5
canonical example family classification
DUF4093 (PF13331)ProteinTraitsMechTOPRIM domainP37547
Ribonuclease M5
canonical example family classification
DUF4093 (PF13331)ProteinTraitsMechDomain of unknown function (DUF4093)P37547
Ribonuclease M5
canonical example family classification
DUF4093 (PF13331)ProteinTraitsMechDomain of unknown function (DUF4093)P47303
Ribonuclease M5
canonical example family classification
DUF4093 (PF13331)ProteinTraitsMechDomain of unknown function (DUF4093)P75045
Ribonuclease M5
canonical example family classification
DUF4093 (PF13331)ProteinTraitsMechDomain of unknown function (DUF4093)
trait identifier
DUF4093 (PF13331)ProteinTraitsMechToprim domainP37547
Ribonuclease M5
canonical example family classification
DUF4093 (PF13331)ProteinTraitsMechToprim domain profileP37547
Ribonuclease M5
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF13331.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.