All families / PF13349
PF13349: DUF4097
Toastrack DUF4097
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF13349: Toastrack DUF4097
IPR025164: integrated entry for Toastrack DUF4097
Source description
This an all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif that has been described as Toastrack DUF4097, whose function is unknown. It has been suggested to form part of a bacterial adhesin. Toastrack has been transferred from bacteria to certain eukaryotes, such as FAM185A from human and its orthologues in animals and other eukaryotes.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
5 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| O32200 | Protein LiaG Bacillus subtilis (strain 168) | 290 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| O34628 | Uncharacterized protein YvlB Bacillus subtilis (strain 168) | 365 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q7TPD2 | Protein FAM185A Mus musculus | 378 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q834B6 | Putative adhesin domain-containing protein LiaX Enterococcus faecalis (strain ATCC 700802 / V583) | 533 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8N0U4 | Protein FAM185A Homo sapiens | 392 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 16,423
- matches
- 16,667
- proteomes
- 8,115
- taxa
- 13,326
- structures
- 0
- alphafold models
- 10,032
- domain architectures
- 69
Classification basis
short name matches duf; description says unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF4097 (PF13349) | ProteinTraitsMech | LiaG family protein | O32200 Protein LiaG | canonical example family classification |
| DUF4097 (PF13349) | ProteinTraitsMech | Toastrack DUF4097 | O32200 Protein LiaG | canonical example family classification |
| DUF4097 (PF13349) | ProteinTraitsMech | Toastrack DUF4097 | O34628 Uncharacterized protein YvlB | canonical example family classification |
| DUF4097 (PF13349) | ProteinTraitsMech | Toastrack DUF4097 | Q7TPD2 Protein FAM185A | canonical example family classification |
| DUF4097 (PF13349) | ProteinTraitsMech | Toastrack DUF4097 | Q8N0U4 Protein FAM185A | canonical example family classification |
| DUF4097 (PF13349) | ProteinTraitsMech | Toastrack DUF4097 | trait identifier | |
| DUF4097 (PF13349) | ProteinTraitsMech | YvlB/LiaX, N-terminal domain | O34628 Uncharacterized protein YvlB | canonical example family classification |
| DUF4097 (PF13349) | ProteinTraitsMech | SHOCT-like domain | O34628 Uncharacterized protein YvlB | canonical example family classification |
| DUF4097 (PF13349) | ProteinTraitsMech | Toastrack DUF4097 | O32200 Protein LiaG | canonical example family classification |
| DUF4097 (PF13349) | ProteinTraitsMech | Toastrack DUF4097 | Q834B6 Putative adhesin domain-containing protein LiaX | canonical example family classification |
| DUF4097 (PF13349) | ProteinTraitsMech | Toastrack DUF4097 | Q8N0U4 Protein FAM185A | canonical example family classification |
| DUF4097 (PF13349) | ProteinTraitsMech | Toastrack DUF4097 | trait identifier | |
| DUF4097 (PF13349) | ProteinTraitsMech | CATH homologous superfamily 2.160.20.120 | O34628 Uncharacterized protein YvlB | canonical example family classification |
| DUF4097 (PF13349) | ProteinTraitsMech | CATH homologous superfamily 2.160.20.120 | Q7TPD2 Protein FAM185A | canonical example family classification |
| DUF4097 (PF13349) | ProteinTraitsMech | CATH homologous superfamily 2.160.20.120 | Q8N0U4 Protein FAM185A | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.