DUFMech

All families / PF13593

PF13593: SBF_like

SBF-like CPA transporter family (DUF4137)

Curation status
SEEDED
Seed status
EX DUF
Characterization
UNSCORED

Grounding

PF13593: SBF-like CPA transporter family (DUF4137)
IPR016833: integrated entry for SBF-like CPA transporter family (DUF4137)

Source description

These family members are 7TM putative membrane transporter proteins. The family is similar to the SBF family of bile-acid symporters, PF01758 (Pfam entry).

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

6 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
F4IZC4Probable sodium/metabolite cotransporter BASS4, chloroplastic
Arabidopsis thaliana
436 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
P39836Putative symporter YfeH
Escherichia coli (strain K12)
332 aa; version 2
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q05131Solute carrier RCH1
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
434 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q0GE19Sodium/bile acid cotransporter 7
Homo sapiens
340 aa; version 2
UniProt 2026_03
PTM REGISTRY MIRROR
4 sibling references
Q3E796Uncharacterized protein YDR182W-A
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
67 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q5PT53Sodium/bile acid cotransporter 7
Mus musculus
340 aa; version 1
UniProt 2026_03
UNIPROT FETCH
3 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
10,043
matches
10,186
proteomes
7,930
taxa
13,544
structures
0
alphafold models
6,899
domain architectures
56

Classification basis

name matches duf; pfam previous unknown name

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
SBF_like (PF13593)ProteinTraitsMechSBF-like CPA transporter family (DUF4137)F4IZC4
Probable sodium/metabolite cotransporter BASS4, chloroplastic
canonical example family classification
SBF_like (PF13593)ProteinTraitsMechSBF-like CPA transporter family (DUF4137)P39836
Putative symporter YfeH
canonical example family classification
SBF_like (PF13593)ProteinTraitsMechSBF-like CPA transporter family (DUF4137)Q05131
Solute carrier RCH1
canonical example family classification
SBF_like (PF13593)ProteinTraitsMechSBF-like CPA transporter family (DUF4137)Q0GE19
Sodium/bile acid cotransporter 7
canonical example family classification
SBF_like (PF13593)ProteinTraitsMechSBF-like CPA transporter family (DUF4137)Q3E796
Uncharacterized protein YDR182W-A
canonical example family classification
SBF_like (PF13593)ProteinTraitsMechSBF-like CPA transporter family (DUF4137)Q5PT53
Sodium/bile acid cotransporter 7
canonical example family classification
SBF_like (PF13593)ProteinTraitsMechSBF-like CPA transporter family (DUF4137)
trait identifier
SBF_like (PF13593)ProteinTraitsMechSodium/solute symporter superfamilyQ0GE19
Sodium/bile acid cotransporter 7
canonical example family classification
SBF_like (PF13593)ProteinTraitsMechSodium/solute symporter superfamilyQ5PT53
Sodium/bile acid cotransporter 7
canonical example family classification
SBF_like (PF13593)ProteinTraitsMechCATH homologous superfamily 1.20.1530.20Q0GE19
Sodium/bile acid cotransporter 7
canonical example family classification
SBF_like (PF13593)ProteinTraitsMechCATH homologous superfamily 1.20.1530.20Q5PT53
Sodium/bile acid cotransporter 7
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF13593.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.