DUFMech

All families / PF13660

PF13660: DUF4147

Domain of unknown function (DUF4147)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF13660: Domain of unknown function (DUF4147)
IPR025286: integrated entry for Domain of unknown function (DUF4147)

Source description

This domain is frequently found at the N-terminus of proteins carrying the glycerate kinase-like domain MOFRL, PF05161 (Pfam entry).

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

6 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O58231Glycerate 2-kinase
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
440 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q09235Uncharacterized protein C13B9.2
Caenorhabditis elegans
458 aa; version 3
UniProt 2026_03
UNIPROT FETCH
8 sibling references
Q8IVS8Glycerate kinase
Homo sapiens
523 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
10 sibling references
Q8QZY2Glycerate kinase
Mus musculus
523 aa; version 1
UniProt 2026_03
UNIPROT FETCH
9 sibling references
Q9VQC4Glycerate kinase
Drosophila melanogaster
487 aa; version 1
UniProt 2026_03
UNIPROT FETCH
8 sibling references
Q9X1S1D-glycerate 2-kinase
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
417 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
6,574
matches
6,602
proteomes
5,579
taxa
10,758
structures
2
alphafold models
4,799
domain architectures
37

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF4147 (PF13660)ProteinTraitsMechglycerate kinase activityQ09235
Uncharacterized protein C13B9.2
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechglycerate kinase activityQ8IVS8
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechglycerate kinase activityQ8QZY2
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechglycerate kinase activityQ9VQC4
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechfructose catabolic processQ8QZY2
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL-associated domainQ09235
Uncharacterized protein C13B9.2
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL-associated domainQ8IVS8
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL-associated domainQ8QZY2
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL-associated domainQ9VQC4
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL-associated domain
trait identifier
DUF4147 (PF13660)ProteinTraitsMechMOFRL domainQ09235
Uncharacterized protein C13B9.2
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL domainQ8IVS8
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL domainQ8QZY2
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL domainQ9VQC4
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechDomain of unknown function (DUF4147)O58231
Glycerate 2-kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechDomain of unknown function (DUF4147)Q8IVS8
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechDomain of unknown function (DUF4147)Q9X1S1
D-glycerate 2-kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechDomain of unknown function (DUF4147)
trait identifier
DUF4147 (PF13660)ProteinTraitsMechMOFRL familyQ09235
Uncharacterized protein C13B9.2
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL familyQ8IVS8
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL familyQ8QZY2
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL familyQ9VQC4
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechGlycerate kinase-like, C-terminal domain superfamilyQ09235
Uncharacterized protein C13B9.2
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechGlycerate kinase-like, C-terminal domain superfamilyQ8IVS8
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechGlycerate kinase-like, C-terminal domain superfamilyQ8QZY2
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechGlycerate kinase-like, C-terminal domain superfamilyQ9VQC4
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechGlycerate kinase, N-terminal domain superfamilyQ09235
Uncharacterized protein C13B9.2
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechGlycerate kinase, N-terminal domain superfamilyQ8IVS8
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechGlycerate kinase, N-terminal domain superfamilyQ8QZY2
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechGlycerate kinase, N-terminal domain superfamilyQ9VQC4
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechGlycerate kinase, MOFRL-like N-terminal domainQ09235
Uncharacterized protein C13B9.2
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechGlycerate kinase, MOFRL-like N-terminal domainQ8IVS8
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechGlycerate kinase, MOFRL-like N-terminal domainQ8QZY2
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechGlycerate kinase, MOFRL-like N-terminal domainQ9VQC4
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL domainQ09235
Uncharacterized protein C13B9.2
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL domainQ8IVS8
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL domainQ8QZY2
Glycerate kinase
canonical example family classification
DUF4147 (PF13660)ProteinTraitsMechMOFRL domainQ9VQC4
Glycerate kinase
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF13660.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.