DUFMech

All families / PF13836

PF13836: DUF4195

Domain of unknown function (DUF4195)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF13836: Domain of unknown function (DUF4195)
IPR025243: integrated entry for Domain of unknown function (DUF4195)

Source description

This family is found at the N-terminus of metazoan proteins that carry PHD-like zinc-finger domains. The function is not known.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

6 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
P59817Zinc finger protein 280A
Homo sapiens
542 aa; version 4
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q68FE8Zinc finger protein 280D
Mus musculus
974 aa; version 1
UniProt 2026_03
UNIPROT FETCH
5 sibling references
Q6N043Zinc finger protein 280D
Homo sapiens
979 aa; version 3
UniProt 2026_03
UNIPROT FETCH
6 sibling references
Q6P3Y5Zinc finger protein 280C
Mus musculus
742 aa; version 1
UniProt 2026_03
UNIPROT FETCH
5 sibling references
Q86YH2Zinc finger protein 280B
Homo sapiens
543 aa; version 3
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q8ND82Zinc finger protein 280C
Homo sapiens
737 aa; version 1
UniProt 2026_03
UNIPROT FETCH
5 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
1,459
matches
1,522
proteomes
422
taxa
1,314
structures
0
alphafold models
1,160
domain architectures
12

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF4195 (PF13836)ProteinTraitsMechDomain of unknown function DUF4195P59817
Zinc finger protein 280A
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechDomain of unknown function DUF4195Q68FE8
Zinc finger protein 280D
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechDomain of unknown function DUF4195Q6N043
Zinc finger protein 280D
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechDomain of unknown function DUF4195Q6P3Y5
Zinc finger protein 280C
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechDomain of unknown function DUF4195Q86YH2
Zinc finger protein 280B
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechDomain of unknown function DUF4195Q8ND82
Zinc finger protein 280C
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechDomain of unknown function DUF4195
trait identifier
DUF4195 (PF13836)ProteinTraitsMechPOGZ/Z280C-D-like, double Zinc fingerQ68FE8
Zinc finger protein 280D
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechPOGZ/Z280C-D-like, double Zinc fingerQ6N043
Zinc finger protein 280D
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechPOGZ/Z280C-D-like, double Zinc fingerQ6P3Y5
Zinc finger protein 280C
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechPOGZ/Z280C-D-like, double Zinc fingerQ8ND82
Zinc finger protein 280C
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechZ280C/D-like, C2H2 zinc fingerQ68FE8
Zinc finger protein 280D
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechZ280C/D-like, C2H2 zinc fingerQ6N043
Zinc finger protein 280D
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechZ280C/D-like, C2H2 zinc fingerQ6P3Y5
Zinc finger protein 280C
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechZ280C/D-like, C2H2 zinc fingerQ8ND82
Zinc finger protein 280C
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechDomain of unknown function (DUF4195)P59817
Zinc finger protein 280A
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechDomain of unknown function (DUF4195)Q6N043
Zinc finger protein 280D
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechDomain of unknown function (DUF4195)Q86YH2
Zinc finger protein 280B
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechDomain of unknown function (DUF4195)
trait identifier
DUF4195 (PF13836)ProteinTraitsMechZ280C/D-like C2H2 zinc fingerQ68FE8
Zinc finger protein 280D
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechZ280C/D-like C2H2 zinc fingerQ6N043
Zinc finger protein 280D
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechZ280C/D-like C2H2 zinc fingerQ6P3Y5
Zinc finger protein 280C
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechZ280C/D-like C2H2 zinc fingerQ8ND82
Zinc finger protein 280C
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechPOGZ-like double zinc fingerQ68FE8
Zinc finger protein 280D
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechPOGZ-like double zinc fingerQ6N043
Zinc finger protein 280D
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechPOGZ-like double zinc fingerQ6P3Y5
Zinc finger protein 280C
canonical example family classification
DUF4195 (PF13836)ProteinTraitsMechPOGZ-like double zinc fingerQ8ND82
Zinc finger protein 280C
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF13836.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.