All families / PF13836
PF13836: DUF4195
Domain of unknown function (DUF4195)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF13836: Domain of unknown function (DUF4195)
IPR025243: integrated entry for Domain of unknown function (DUF4195)
Source description
This family is found at the N-terminus of metazoan proteins that carry PHD-like zinc-finger domains. The function is not known.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
6 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| P59817 | Zinc finger protein 280A Homo sapiens | 542 aa; version 4 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q68FE8 | Zinc finger protein 280D Mus musculus | 974 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q6N043 | Zinc finger protein 280D Homo sapiens | 979 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| Q6P3Y5 | Zinc finger protein 280C Mus musculus | 742 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q86YH2 | Zinc finger protein 280B Homo sapiens | 543 aa; version 3 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q8ND82 | Zinc finger protein 280C Homo sapiens | 737 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 1,459
- matches
- 1,522
- proteomes
- 422
- taxa
- 1,314
- structures
- 0
- alphafold models
- 1,160
- domain architectures
- 12
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF4195 (PF13836) | ProteinTraitsMech | Domain of unknown function DUF4195 | P59817 Zinc finger protein 280A | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Domain of unknown function DUF4195 | Q68FE8 Zinc finger protein 280D | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Domain of unknown function DUF4195 | Q6N043 Zinc finger protein 280D | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Domain of unknown function DUF4195 | Q6P3Y5 Zinc finger protein 280C | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Domain of unknown function DUF4195 | Q86YH2 Zinc finger protein 280B | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Domain of unknown function DUF4195 | Q8ND82 Zinc finger protein 280C | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Domain of unknown function DUF4195 | trait identifier | |
| DUF4195 (PF13836) | ProteinTraitsMech | POGZ/Z280C-D-like, double Zinc finger | Q68FE8 Zinc finger protein 280D | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | POGZ/Z280C-D-like, double Zinc finger | Q6N043 Zinc finger protein 280D | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | POGZ/Z280C-D-like, double Zinc finger | Q6P3Y5 Zinc finger protein 280C | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | POGZ/Z280C-D-like, double Zinc finger | Q8ND82 Zinc finger protein 280C | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Z280C/D-like, C2H2 zinc finger | Q68FE8 Zinc finger protein 280D | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Z280C/D-like, C2H2 zinc finger | Q6N043 Zinc finger protein 280D | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Z280C/D-like, C2H2 zinc finger | Q6P3Y5 Zinc finger protein 280C | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Z280C/D-like, C2H2 zinc finger | Q8ND82 Zinc finger protein 280C | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Domain of unknown function (DUF4195) | P59817 Zinc finger protein 280A | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Domain of unknown function (DUF4195) | Q6N043 Zinc finger protein 280D | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Domain of unknown function (DUF4195) | Q86YH2 Zinc finger protein 280B | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Domain of unknown function (DUF4195) | trait identifier | |
| DUF4195 (PF13836) | ProteinTraitsMech | Z280C/D-like C2H2 zinc finger | Q68FE8 Zinc finger protein 280D | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Z280C/D-like C2H2 zinc finger | Q6N043 Zinc finger protein 280D | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Z280C/D-like C2H2 zinc finger | Q6P3Y5 Zinc finger protein 280C | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | Z280C/D-like C2H2 zinc finger | Q8ND82 Zinc finger protein 280C | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | POGZ-like double zinc finger | Q68FE8 Zinc finger protein 280D | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | POGZ-like double zinc finger | Q6N043 Zinc finger protein 280D | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | POGZ-like double zinc finger | Q6P3Y5 Zinc finger protein 280C | canonical example family classification |
| DUF4195 (PF13836) | ProteinTraitsMech | POGZ-like double zinc finger | Q8ND82 Zinc finger protein 280C | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.