DUFMech

All families / PF13915

PF13915: DUF4210

Domain of unknown function (DUF4210)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF13915: Domain of unknown function (DUF4210)
IPR025261: integrated entry for Domain of unknown function (DUF4210)

Source description

This short domain is found in fungi, plants and animals, and the proteins appear to be necessary for chromosome segregation during meiosis.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

5 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
Q32MH5Atos homolog protein A
Homo sapiens
1076 aa; version 2
UniProt 2026_03
PTM REGISTRY MIRROR
5 sibling references
Q69ZK7Atos homolog protein A
Mus musculus
1075 aa; version 3
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q7JXG9Protein Atossa
Drosophila melanogaster
1297 aa; version 1
UniProt 2026_03
UNIPROT FETCH
4 sibling references
Q7L5A3Atos homolog protein B
Homo sapiens
538 aa; version 1
UniProt 2026_03
UNIPROT FETCH
4 sibling references
Q8BR27Atos homolog protein B
Mus musculus
538 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
3,976
matches
3,979
proteomes
2,444
taxa
6,680
structures
0
alphafold models
3,265
domain architectures
39

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF4210 (PF13915)ProteinTraitsMechAtos-like, C-terminalQ32MH5
Atos homolog protein A
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechAtos-like, C-terminalQ69ZK7
Atos homolog protein A
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechAtos-like, C-terminalQ7JXG9
Protein Atossa
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechAtos-like, C-terminalQ7L5A3
Atos homolog protein B
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechAtos-like, C-terminalQ8BR27
Atos homolog protein B
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechAtos-like, conserved domainQ32MH5
Atos homolog protein A
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechAtos-like, conserved domainQ69ZK7
Atos homolog protein A
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechAtos-like, conserved domainQ7JXG9
Protein Atossa
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechAtos-like, conserved domainQ7L5A3
Atos homolog protein B
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechAtos-like, conserved domainQ8BR27
Atos homolog protein B
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechAtos-like, conserved domain
trait identifier
DUF4210 (PF13915)ProteinTraitsMechDomain of unknown function (DUF4210)Q32MH5
Atos homolog protein A
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechDomain of unknown function (DUF4210)Q7JXG9
Protein Atossa
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechDomain of unknown function (DUF4210)Q7L5A3
Atos homolog protein B
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechDomain of unknown function (DUF4210)
trait identifier
DUF4210 (PF13915)ProteinTraitsMechChromosome segregation during meiosisQ32MH5
Atos homolog protein A
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechChromosome segregation during meiosisQ7JXG9
Protein Atossa
canonical example family classification
DUF4210 (PF13915)ProteinTraitsMechChromosome segregation during meiosisQ7L5A3
Atos homolog protein B
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF13915.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.