DUFMech

All families / PF15094

PF15094: DUF4556

Domain of unknown function (DUF4556), Ig-like

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF15094: Domain of unknown function (DUF4556), Ig-like
IPR049521: integrated entry for Domain of unknown function (DUF4556), Ig-like

Source description

This entry represents a immunoglobulin-like domain found in a functionally uncharacterised protein family. This family of proteins is found in vertebrates and includes human protein C1orf127.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

3 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
B1ARY8Ciliated left-right organizer ZP-N domains-containing protein
Mus musculus
786 aa; version 2
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q8N9H9Ciliated left-right organizer ZP-N domains-containing protein
Homo sapiens
823 aa; version 3
UniProt 2026_03
UNIPROT FETCH
2 sibling references
X1WBN4Ciliated left-right organizer protein containing ZP-N domains homolog
Danio rerio
432 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
213
matches
215
proteomes
160
taxa
608
structures
0
alphafold models
156
domain architectures
5

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF4556 (PF15094)ProteinTraitsMechCIROZ, beta domainB1ARY8
Ciliated left-right organizer ZP-N domains-containing protein
canonical example family classification
DUF4556 (PF15094)ProteinTraitsMechCIROZ, beta domainQ8N9H9
Ciliated left-right organizer ZP-N domains-containing protein
canonical example family classification
DUF4556 (PF15094)ProteinTraitsMechCIROZ, beta domain
trait identifier
DUF4556 (PF15094)ProteinTraitsMechDomain of unknown function (DUF4556), Ig-likeB1ARY8
Ciliated left-right organizer ZP-N domains-containing protein
canonical example family classification
DUF4556 (PF15094)ProteinTraitsMechDomain of unknown function (DUF4556), Ig-likeQ8N9H9
Ciliated left-right organizer ZP-N domains-containing protein
canonical example family classification
DUF4556 (PF15094)ProteinTraitsMechDomain of unknown function (DUF4556), Ig-likeX1WBN4
Ciliated left-right organizer protein containing ZP-N domains homolog
canonical example family classification
DUF4556 (PF15094)ProteinTraitsMechDomain of unknown function (DUF4556), Ig-like
trait identifier

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF15094.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.