All families / PF15371
PF15371: DUF4599
Domain of unknown function (DUF4599)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF15371: Domain of unknown function (DUF4599)
IPR027970: integrated entry for Domain of unknown function (DUF4599)
Source description
The function of this family of eukaryotic proteins is not known.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
9 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A6NFA0 | Protein SPATA31F3 Homo sapiens | 338 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| B4DYI2 | Spermatogenesis-associated protein 31C2 Homo sapiens | 1134 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| P0C874 | Spermatogenesis-associated protein 31D3 Homo sapiens | 917 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| P0DKV0 | Spermatogenesis-associated protein 31C1 Homo sapiens | 1188 aa; version 1 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q5TZJ5 | Spermatogenesis-associated protein 31A1 Homo sapiens | 1347 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q5VU36 | Spermatogenesis-associated protein 31A5 Homo sapiens | 1347 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q5VVP1 | Spermatogenesis-associated protein 31A6 Homo sapiens | 1343 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q6ZUB1 | Spermatogenesis-associated protein 31E1 Homo sapiens | 1445 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q80YD3 | Protein SPATA31F3 Mus musculus | 371 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 1,009
- matches
- 1,015
- proteomes
- 152
- taxa
- 476
- structures
- 0
- alphafold models
- 418
- domain architectures
- 14
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31 | B4DYI2 Spermatogenesis-associated protein 31C2 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31 | P0C874 Spermatogenesis-associated protein 31D3 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31 | P0DKV0 Spermatogenesis-associated protein 31C1 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31 | Q5TZJ5 Spermatogenesis-associated protein 31A1 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31 | Q5VU36 Spermatogenesis-associated protein 31A5 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31 | Q5VVP1 Spermatogenesis-associated protein 31A6 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31-like | A6NFA0 Protein SPATA31F3 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31-like | B4DYI2 Spermatogenesis-associated protein 31C2 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31-like | P0C874 Spermatogenesis-associated protein 31D3 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31-like | P0DKV0 Spermatogenesis-associated protein 31C1 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31-like | Q5TZJ5 Spermatogenesis-associated protein 31A1 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31-like | Q5VU36 Spermatogenesis-associated protein 31A5 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31-like | Q5VVP1 Spermatogenesis-associated protein 31A6 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31-like | Q80YD3 Protein SPATA31F3 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | SPATA31-like | trait identifier | |
| DUF4599 (PF15371) | ProteinTraitsMech | Domain of unknown function (DUF4599) | P0DKV0 Spermatogenesis-associated protein 31C1 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | Domain of unknown function (DUF4599) | Q5TZJ5 Spermatogenesis-associated protein 31A1 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | Domain of unknown function (DUF4599) | Q6ZUB1 Spermatogenesis-associated protein 31E1 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | Domain of unknown function (DUF4599) | trait identifier | |
| DUF4599 (PF15371) | ProteinTraitsMech | FAM75 family | P0DKV0 Spermatogenesis-associated protein 31C1 | canonical example family classification |
| DUF4599 (PF15371) | ProteinTraitsMech | FAM75 family | Q6ZUB1 Spermatogenesis-associated protein 31E1 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.