DUFMech

All families / PF15371

PF15371: DUF4599

Domain of unknown function (DUF4599)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF15371: Domain of unknown function (DUF4599)
IPR027970: integrated entry for Domain of unknown function (DUF4599)

Source description

The function of this family of eukaryotic proteins is not known.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

9 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
A6NFA0Protein SPATA31F3
Homo sapiens
338 aa; version 2
UniProt 2026_03
UNIPROT FETCH
1 sibling references
B4DYI2Spermatogenesis-associated protein 31C2
Homo sapiens
1134 aa; version 2
UniProt 2026_03
UNIPROT FETCH
2 sibling references
P0C874Spermatogenesis-associated protein 31D3
Homo sapiens
917 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references
P0DKV0Spermatogenesis-associated protein 31C1
Homo sapiens
1188 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
5 sibling references
Q5TZJ5Spermatogenesis-associated protein 31A1
Homo sapiens
1347 aa; version 1
UniProt 2026_03
UNIPROT FETCH
3 sibling references
Q5VU36Spermatogenesis-associated protein 31A5
Homo sapiens
1347 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q5VVP1Spermatogenesis-associated protein 31A6
Homo sapiens
1343 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q6ZUB1Spermatogenesis-associated protein 31E1
Homo sapiens
1445 aa; version 2
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q80YD3Protein SPATA31F3
Mus musculus
371 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
1,009
matches
1,015
proteomes
152
taxa
476
structures
0
alphafold models
418
domain architectures
14

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF4599 (PF15371)ProteinTraitsMechSPATA31B4DYI2
Spermatogenesis-associated protein 31C2
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31P0C874
Spermatogenesis-associated protein 31D3
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31P0DKV0
Spermatogenesis-associated protein 31C1
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31Q5TZJ5
Spermatogenesis-associated protein 31A1
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31Q5VU36
Spermatogenesis-associated protein 31A5
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31Q5VVP1
Spermatogenesis-associated protein 31A6
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31-likeA6NFA0
Protein SPATA31F3
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31-likeB4DYI2
Spermatogenesis-associated protein 31C2
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31-likeP0C874
Spermatogenesis-associated protein 31D3
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31-likeP0DKV0
Spermatogenesis-associated protein 31C1
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31-likeQ5TZJ5
Spermatogenesis-associated protein 31A1
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31-likeQ5VU36
Spermatogenesis-associated protein 31A5
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31-likeQ5VVP1
Spermatogenesis-associated protein 31A6
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31-likeQ80YD3
Protein SPATA31F3
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechSPATA31-like
trait identifier
DUF4599 (PF15371)ProteinTraitsMechDomain of unknown function (DUF4599)P0DKV0
Spermatogenesis-associated protein 31C1
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechDomain of unknown function (DUF4599)Q5TZJ5
Spermatogenesis-associated protein 31A1
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechDomain of unknown function (DUF4599)Q6ZUB1
Spermatogenesis-associated protein 31E1
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechDomain of unknown function (DUF4599)
trait identifier
DUF4599 (PF15371)ProteinTraitsMechFAM75 familyP0DKV0
Spermatogenesis-associated protein 31C1
canonical example family classification
DUF4599 (PF15371)ProteinTraitsMechFAM75 familyQ6ZUB1
Spermatogenesis-associated protein 31E1
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF15371.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.