DUFMech

All families / PF15787

PF15787: DUF4704

Neurobeachin/BDCP, DUF4704 alpha solenoid region

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF15787: Neurobeachin/BDCP, DUF4704 alpha solenoid region
IPR031570: integrated entry for Neurobeachin/BDCP, DUF4704 alpha solenoid region

Source description

This domain of unknown function is found in eukaryotes on neurobeachin and BEACH domain-containing proteins (BDCPs) [InterPro reference PUB00075927,InterPro reference PUB00098184]. Mutations in this proteins are associated with Lipopolysaccharide-responsive and beige-like anchor (LRBA) deficiency [InterPro reference PUB00098184]. According to structure prediction is adopts an alpha-helical solenoid structure.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

6 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
P0C6P0Putative protein BCL8
Homo sapiens
100 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
P50851Lipopolysaccharide-responsive and beige-like anchor protein
Homo sapiens
2863 aa; version 4
UniProt 2026_03
PTM REGISTRY MIRROR
6 sibling references
Q6ZNJ1Neurobeachin-like protein 2
Homo sapiens
2754 aa; version 2
UniProt 2026_03
UNIPROT FETCH
4 sibling references
Q6ZQA0Neurobeachin-like protein 2
Mus musculus
2742 aa; version 2
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q8NFP9Neurobeachin
Homo sapiens
2946 aa; version 3
UniProt 2026_03
UNIPROT FETCH
4 sibling references
Q9W4E2Neurobeachin
Drosophila melanogaster
3466 aa; version 4
UniProt 2026_03
UNIPROT FETCH
1 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
10,161
matches
11,316
proteomes
1,996
taxa
6,072
structures
0
alphafold models
510
domain architectures
349

Classification basis

short name matches duf; description says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin/BDCP, DUF4704P0C6P0
Putative protein BCL8
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin/BDCP, DUF4704
trait identifier
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin-like, DUF1088P50851
Lipopolysaccharide-responsive and beige-like anchor protein
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin-like, DUF1088Q8NFP9
Neurobeachin
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin-like, DUF1088Q9W4E2
Neurobeachin
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechBeige/BEACH domainP50851
Lipopolysaccharide-responsive and beige-like anchor protein
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechDomain of unknown function (DUF4800)Q6ZNJ1
Neurobeachin-like protein 2
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechDomain of unknown function (DUF4800)Q6ZQA0
Neurobeachin-like protein 2
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin/BDCP, DUF4704 alpha solenoid regionP50851
Lipopolysaccharide-responsive and beige-like anchor protein
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin/BDCP, DUF4704 alpha solenoid regionQ6ZNJ1
Neurobeachin-like protein 2
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin/BDCP, DUF4704 alpha solenoid regionQ8NFP9
Neurobeachin
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin/BDCP, DUF4704 alpha solenoid region
trait identifier
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin beta propeller domainP50851
Lipopolysaccharide-responsive and beige-like anchor protein
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin beta propeller domainQ6ZNJ1
Neurobeachin-like protein 2
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin beta propeller domainQ8NFP9
Neurobeachin
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin alpha solenoid regionP50851
Lipopolysaccharide-responsive and beige-like anchor protein
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin alpha solenoid regionQ6ZNJ1
Neurobeachin-like protein 2
canonical example family classification
DUF4704 (PF15787)ProteinTraitsMechNeurobeachin alpha solenoid regionQ8NFP9
Neurobeachin
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF15787.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.