All families / PF15787
PF15787: DUF4704
Neurobeachin/BDCP, DUF4704 alpha solenoid region
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF15787: Neurobeachin/BDCP, DUF4704 alpha solenoid region
IPR031570: integrated entry for Neurobeachin/BDCP, DUF4704 alpha solenoid region
Source description
This domain of unknown function is found in eukaryotes on neurobeachin and BEACH domain-containing proteins (BDCPs) [InterPro reference PUB00075927,InterPro reference PUB00098184]. Mutations in this proteins are associated with Lipopolysaccharide-responsive and beige-like anchor (LRBA) deficiency [InterPro reference PUB00098184]. According to structure prediction is adopts an alpha-helical solenoid structure.
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
6 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| P0C6P0 | Putative protein BCL8 Homo sapiens | 100 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P50851 | Lipopolysaccharide-responsive and beige-like anchor protein Homo sapiens | 2863 aa; version 4 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q6ZNJ1 | Neurobeachin-like protein 2 Homo sapiens | 2754 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q6ZQA0 | Neurobeachin-like protein 2 Mus musculus | 2742 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8NFP9 | Neurobeachin Homo sapiens | 2946 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| Q9W4E2 | Neurobeachin Drosophila melanogaster | 3466 aa; version 4 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 10,161
- matches
- 11,316
- proteomes
- 1,996
- taxa
- 6,072
- structures
- 0
- alphafold models
- 510
- domain architectures
- 349
Classification basis
short name matches duf; description says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin/BDCP, DUF4704 | P0C6P0 Putative protein BCL8 | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin/BDCP, DUF4704 | trait identifier | |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin-like, DUF1088 | P50851 Lipopolysaccharide-responsive and beige-like anchor protein | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin-like, DUF1088 | Q8NFP9 Neurobeachin | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin-like, DUF1088 | Q9W4E2 Neurobeachin | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Beige/BEACH domain | P50851 Lipopolysaccharide-responsive and beige-like anchor protein | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Domain of unknown function (DUF4800) | Q6ZNJ1 Neurobeachin-like protein 2 | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Domain of unknown function (DUF4800) | Q6ZQA0 Neurobeachin-like protein 2 | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin/BDCP, DUF4704 alpha solenoid region | P50851 Lipopolysaccharide-responsive and beige-like anchor protein | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin/BDCP, DUF4704 alpha solenoid region | Q6ZNJ1 Neurobeachin-like protein 2 | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin/BDCP, DUF4704 alpha solenoid region | Q8NFP9 Neurobeachin | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin/BDCP, DUF4704 alpha solenoid region | trait identifier | |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin beta propeller domain | P50851 Lipopolysaccharide-responsive and beige-like anchor protein | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin beta propeller domain | Q6ZNJ1 Neurobeachin-like protein 2 | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin beta propeller domain | Q8NFP9 Neurobeachin | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin alpha solenoid region | P50851 Lipopolysaccharide-responsive and beige-like anchor protein | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin alpha solenoid region | Q6ZNJ1 Neurobeachin-like protein 2 | canonical example family classification |
| DUF4704 (PF15787) | ProteinTraitsMech | Neurobeachin alpha solenoid region | Q8NFP9 Neurobeachin | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.