All families / PF16355
PF16355: DUF4982
Domain of unknown function (DUF4982)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF16355: Domain of unknown function (DUF4982)
IPR032311: integrated entry for Domain of unknown function (DUF4982)
Source description
This domain is found towards the C terminus of Beta-glucuronidase from Formosa agariphila (P17_GH2) and similar proteins mainly from bacteria and fungi. P17_GH2 is involved in the degradation of the polysaccharide ulvan. The function of this domain, which shows an all-beta structure, is unknown [InterPro reference PUB00093668].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
4 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A7LXS9 | Beta-galactosidase BoGH2A Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC 11153) | 851 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q5LIC7 | Beta-glucuronidase Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / LMG 10263 / NCTC 9343 / Onslow / VPI 2553 / EN-2) | 695 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| T2KM09 | Putative beta-glucuronidase Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) | 1034 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| T2KN75 | Beta-glucuronidase Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) | 981 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 7,504
- matches
- 7,520
- proteomes
- 3,206
- taxa
- 5,073
- structures
- 40
- alphafold models
- 4,667
- domain architectures
- 279
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF4982 (PF16355) | ProteinTraitsMech | Domain of unknown function DUF4982 | trait identifier | |
| DUF4982 (PF16355) | ProteinTraitsMech | Domain of unknown function (DUF4982) | A7LXS9 Beta-galactosidase BoGH2A | canonical example family classification |
| DUF4982 (PF16355) | ProteinTraitsMech | Domain of unknown function (DUF4982) | Q5LIC7 Beta-glucuronidase | canonical example family classification |
| DUF4982 (PF16355) | ProteinTraitsMech | Domain of unknown function (DUF4982) | T2KM09 Putative beta-glucuronidase | canonical example family classification |
| DUF4982 (PF16355) | ProteinTraitsMech | Domain of unknown function (DUF4982) | trait identifier | |
| DUF4982 (PF16355) | ProteinTraitsMech | Glycoside hydrolase family 2 C-terminal domain 5 | A7LXS9 Beta-galactosidase BoGH2A | canonical example family classification |
| DUF4982 (PF16355) | ProteinTraitsMech | Glycoside hydrolase family 2 C-terminal domain 5 | T2KN75 Beta-glucuronidase | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.