All families / PF17661
PF17661: DUF5523
Family of unknown function (DUF5523)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF17661: Family of unknown function (DUF5523)
IPR041510: integrated entry for Family of unknown function (DUF5523)
Source description
This is a family of unknown function found in Eukaryotes. Family members such as the human CC1D2A protein Q9P2K1 (UniProtKB protein), carry the domain architecture where PF15625 (Pfam entry) and PF00168 (Pfam entry) are found at the C-terminal region of this family. However, other family members such as D6R9V3 (UniProtKB protein), do not carry either of the above mentioned Pfam families.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q6DHV5 | Protein CC2D2B Homo sapiens | 1437 aa; version 4 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q8CFW7 | Coiled-coil and C2 domain-containing protein 2A Mus musculus | 1633 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q9P2K1 | Coiled-coil and C2 domain-containing protein 2A Homo sapiens | 1620 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 1,522
- matches
- 1,553
- proteomes
- 645
- taxa
- 2,391
- structures
- 0
- alphafold models
- 316
- domain architectures
- 39
Classification basis
short name matches duf; name says unknown function; description says unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF5523 (PF17661) | ProteinTraitsMech | CC2D2A, N-terminal, C2 domain | Q6DHV5 Protein CC2D2B | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | CC2D2A, N-terminal, C2 domain | Q8CFW7 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | CC2D2A, N-terminal, C2 domain | Q9P2K1 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Centrosomal protein of 76 kDa, C-terminal | Q6DHV5 Protein CC2D2B | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Centrosomal protein of 76 kDa, C-terminal | Q8CFW7 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Centrosomal protein of 76 kDa, C-terminal | Q9P2K1 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | CEP76/DRC7, peptidase-like domain | Q8CFW7 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | CEP76/DRC7, peptidase-like domain | Q9P2K1 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Domain of unknown function DUF5523 | Q6DHV5 Protein CC2D2B | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Domain of unknown function DUF5523 | Q8CFW7 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Domain of unknown function DUF5523 | Q9P2K1 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Domain of unknown function DUF5523 | trait identifier | |
| DUF5523 (PF17661) | ProteinTraitsMech | CC2D2A N-terminal C2 domain | Q6DHV5 Protein CC2D2B | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | CC2D2A N-terminal C2 domain | Q8CFW7 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | CC2D2A N-terminal C2 domain | Q9P2K1 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Centrosomal protein of 76 kDa C-terminal domain | Q8CFW7 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Centrosomal protein of 76 kDa C-terminal domain | Q9P2K1 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | CEP76 peptidase-like domain | Q9P2K1 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Family of unknown function (DUF5523) | Q6DHV5 Protein CC2D2B | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Family of unknown function (DUF5523) | Q8CFW7 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Family of unknown function (DUF5523) | Q9P2K1 Coiled-coil and C2 domain-containing protein 2A | canonical example family classification |
| DUF5523 (PF17661) | ProteinTraitsMech | Family of unknown function (DUF5523) | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.