DUFMech

All families / PF17744

PF17744: DUF5581

Family of unknown function (DUF5581) Fn3-like domain

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF17744: Family of unknown function (DUF5581) Fn3-like domain
IPR048317: integrated entry for Family of unknown function (DUF5581) Fn3-like domain

Source description

This is a family of unknown function found in chordates. This entry represents a C-terminal fibronectin type III domain.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

3 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
Q2T9Z2Fibronectin type III domain-containing protein 11
Bos taurus		333 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q80WB0Fibronectin type III domain-containing protein 11
Mus musculus		326 aa; version 1
UniProt 2026_03		UNIPROT FETCH
4 sibling references
Q9BVV2Fibronectin type III domain-containing protein 11
Homo sapiens		318 aa; version 1
UniProt 2026_03		PTM REGISTRY MIRROR
5 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
408
matches
408
proteomes
373
taxa
1,247
structures
0
alphafold models
363
domain architectures
2

Classification basis

short name matches duf; name says unknown function; description says unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF5581 (PF17744)ProteinTraitsMechDUF5581, Fn3-like domainQ80WB0
Fibronectin type III domain-containing protein 11		canonical example family classification
DUF5581 (PF17744)ProteinTraitsMechDUF5581, Fn3-like domainQ9BVV2
Fibronectin type III domain-containing protein 11		canonical example family classification
DUF5581 (PF17744)ProteinTraitsMechDUF5581, Fn3-like domain
trait identifier
DUF5581 (PF17744)ProteinTraitsMechDUF5581, N-terminal domainQ80WB0
Fibronectin type III domain-containing protein 11		canonical example family classification
DUF5581 (PF17744)ProteinTraitsMechDUF5581, N-terminal domainQ9BVV2
Fibronectin type III domain-containing protein 11		canonical example family classification
DUF5581 (PF17744)ProteinTraitsMechFamily of unknown function (DUF5581) Fn3-like domainQ2T9Z2
Fibronectin type III domain-containing protein 11		canonical example family classification
DUF5581 (PF17744)ProteinTraitsMechFamily of unknown function (DUF5581) Fn3-like domainQ80WB0
Fibronectin type III domain-containing protein 11		canonical example family classification
DUF5581 (PF17744)ProteinTraitsMechFamily of unknown function (DUF5581) Fn3-like domainQ9BVV2
Fibronectin type III domain-containing protein 11		canonical example family classification
DUF5581 (PF17744)ProteinTraitsMechFamily of unknown function (DUF5581) Fn3-like domain
trait identifier
DUF5581 (PF17744)ProteinTraitsMechFamily of unknown function (DUF5581) N-terminal domainQ2T9Z2
Fibronectin type III domain-containing protein 11		canonical example family classification
DUF5581 (PF17744)ProteinTraitsMechFamily of unknown function (DUF5581) N-terminal domainQ80WB0
Fibronectin type III domain-containing protein 11		canonical example family classification
DUF5581 (PF17744)ProteinTraitsMechFamily of unknown function (DUF5581) N-terminal domainQ9BVV2
Fibronectin type III domain-containing protein 11		canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF17744.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.