All families / PF18077
PF18077: DUF5595
Domain of unknown function (DUF5595)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF18077: Domain of unknown function (DUF5595)
IPR040967: integrated entry for Domain of unknown function (DUF5595)
Source description
This domain is found in Nude C 80 (Ndc80) proteins which can be found in species such as Homo sapiens. Ndc80 protein complexes are a core component of the end-on attachment sites for kinetochore microtubules. Ndc80 is also known as Hec1, for highly expressed in cancer 1 [InterPro reference PUB00049694].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
4 verified sequence examples. FASTA
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 1,048
- matches
- 1,048
- proteomes
- 866
- taxa
- 2,717
- structures
- 12
- alphafold models
- 931
- domain architectures
- 23
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF5595 (PF18077) | ProteinTraitsMech | Ndc80 complex | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Ndc80 complex | P40460 Kinetochore protein NDC80 | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Ndc80 complex | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | kinetochore adaptor activity | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | kinetochore adaptor activity | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | G2/MI transition of meiotic cell cycle | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | G2/MI transition of meiotic cell cycle | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | skeletal muscle satellite cell proliferation | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | spindle assembly involved in female meiosis I | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | spindle assembly involved in female meiosis I | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Domain of unknown function DUF5595 | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Domain of unknown function DUF5595 | P40460 Kinetochore protein NDC80 | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Domain of unknown function DUF5595 | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Domain of unknown function DUF5595 | trait identifier | |
| DUF5595 (PF18077) | ProteinTraitsMech | Kinetochore protein Ndc80, CH domain | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Kinetochore protein Ndc80, CH domain | P40460 Kinetochore protein NDC80 | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Kinetochore protein Ndc80, CH domain | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Kinetochore protein NDC80 loop region | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Kinetochore protein NDC80 loop region | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Domain of unknown function (DUF5595) | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Domain of unknown function (DUF5595) | P40460 Kinetochore protein NDC80 | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Domain of unknown function (DUF5595) | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Domain of unknown function (DUF5595) | trait identifier | |
| DUF5595 (PF18077) | ProteinTraitsMech | HEC/Ndc80p family | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | HEC/Ndc80p family | P40460 Kinetochore protein NDC80 | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | HEC/Ndc80p family | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Kinetochore protein NDC80 loop region | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Kinetochore protein NDC80 loop region | Q76I89 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Kinetochore protein NDC80 loop region | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Ndc80 domain superfamily | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Ndc80 domain superfamily | P40460 Kinetochore protein NDC80 | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Ndc80 domain superfamily | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | CATH homologous superfamily 6.10.250.1950 | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | CATH homologous superfamily 6.10.250.1950 | P40460 Kinetochore protein NDC80 | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | CATH homologous superfamily 6.10.250.1950 | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Ncd80 complex, Ncd80 subunit | O14777 Kinetochore protein NDC80 homolog | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Ncd80 complex, Ncd80 subunit | P40460 Kinetochore protein NDC80 | canonical example family classification |
| DUF5595 (PF18077) | ProteinTraitsMech | Ncd80 complex, Ncd80 subunit | Q9D0F1 Kinetochore protein NDC80 homolog | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.