DUFMech

All families / PF18077

PF18077: DUF5595

Domain of unknown function (DUF5595)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF18077: Domain of unknown function (DUF5595)
IPR040967: integrated entry for Domain of unknown function (DUF5595)

Source description

This domain is found in Nude C 80 (Ndc80) proteins which can be found in species such as Homo sapiens. Ndc80 protein complexes are a core component of the end-on attachment sites for kinetochore microtubules. Ndc80 is also known as Hec1, for highly expressed in cancer 1 [InterPro reference PUB00049694].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

4 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O14777Kinetochore protein NDC80 homolog
Homo sapiens
642 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
14 sibling references
P40460Kinetochore protein NDC80
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
691 aa; version 1
UniProt 2026_03
UNIPROT FETCH
8 sibling references
Q76I89Kinetochore protein NDC80 homolog
Gallus gallus
640 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q9D0F1Kinetochore protein NDC80 homolog
Mus musculus
642 aa; version 1
UniProt 2026_03
UNIPROT FETCH
14 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
1,048
matches
1,048
proteomes
866
taxa
2,717
structures
12
alphafold models
931
domain architectures
23

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF5595 (PF18077)ProteinTraitsMechNdc80 complexO14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechNdc80 complexP40460
Kinetochore protein NDC80
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechNdc80 complexQ9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechkinetochore adaptor activityO14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechkinetochore adaptor activityQ9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechG2/MI transition of meiotic cell cycleO14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechG2/MI transition of meiotic cell cycleQ9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechskeletal muscle satellite cell proliferationQ9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechspindle assembly involved in female meiosis IO14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechspindle assembly involved in female meiosis IQ9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechDomain of unknown function DUF5595O14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechDomain of unknown function DUF5595P40460
Kinetochore protein NDC80
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechDomain of unknown function DUF5595Q9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechDomain of unknown function DUF5595
trait identifier
DUF5595 (PF18077)ProteinTraitsMechKinetochore protein Ndc80, CH domainO14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechKinetochore protein Ndc80, CH domainP40460
Kinetochore protein NDC80
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechKinetochore protein Ndc80, CH domainQ9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechKinetochore protein NDC80 loop regionO14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechKinetochore protein NDC80 loop regionQ9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechDomain of unknown function (DUF5595)O14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechDomain of unknown function (DUF5595)P40460
Kinetochore protein NDC80
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechDomain of unknown function (DUF5595)Q9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechDomain of unknown function (DUF5595)
trait identifier
DUF5595 (PF18077)ProteinTraitsMechHEC/Ndc80p familyO14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechHEC/Ndc80p familyP40460
Kinetochore protein NDC80
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechHEC/Ndc80p familyQ9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechKinetochore protein NDC80 loop regionO14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechKinetochore protein NDC80 loop regionQ76I89
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechKinetochore protein NDC80 loop regionQ9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechNdc80 domain superfamilyO14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechNdc80 domain superfamilyP40460
Kinetochore protein NDC80
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechNdc80 domain superfamilyQ9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechCATH homologous superfamily 6.10.250.1950O14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechCATH homologous superfamily 6.10.250.1950P40460
Kinetochore protein NDC80
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechCATH homologous superfamily 6.10.250.1950Q9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechNcd80 complex, Ncd80 subunitO14777
Kinetochore protein NDC80 homolog
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechNcd80 complex, Ncd80 subunitP40460
Kinetochore protein NDC80
canonical example family classification
DUF5595 (PF18077)ProteinTraitsMechNcd80 complex, Ncd80 subunitQ9D0F1
Kinetochore protein NDC80 homolog
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF18077.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.