DUFMech

All families / PF18151

PF18151: DUF5601

Domain of unknown function (DUF5601)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF18151: Domain of unknown function (DUF5601)
IPR041545: integrated entry for Domain of unknown function (DUF5601)

Source description

This domain is found in the catalytic core RABEX-5 present in Homo sapiens. RABEX, also known as Rab GTPase exchange factors, regulate endocytic trafficking through activation of the Rab families RAB5, RAB21 and RAB22. The domain is helical in nature [InterPro reference PUB00042275].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

6 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
O18973Rab5 GDP/GTP exchange factor
Bos taurus
492 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
P54787Vacuolar protein sorting-associated protein 9
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
451 aa; version 2
UniProt 2026_03
PTM REGISTRY MIRROR
1 sibling references
Q14C86GTPase-activating protein and VPS9 domain-containing protein 1
Homo sapiens
1478 aa; version 2
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q9JM13Rab5 GDP/GTP exchange factor
Mus musculus
491 aa; version 1
UniProt 2026_03
UNIPROT FETCH
16 sibling references
Q9LT31Vacuolar protein sorting-associated protein 9A
Arabidopsis thaliana
520 aa; version 1
UniProt 2026_03
UNIPROT FETCH
10 sibling references
Q9UJ41Rab5 GDP/GTP exchange factor
Homo sapiens
491 aa; version 3
UniProt 2026_03
UNIPROT FETCH
8 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
6,756
matches
6,758
proteomes
3,165
taxa
8,367
structures
9
alphafold models
4,099
domain architectures
99

Classification basis

short name matches duf; name says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF5601 (PF18151)ProteinTraitsMechcell plate assemblyQ9LT31
Vacuolar protein sorting-associated protein 9A
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechcell wall biogenesisQ9LT31
Vacuolar protein sorting-associated protein 9A
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechdendritic transportQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechdendritic transportQ9UJ41
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechnegative regulation of Kit signaling pathwayQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechnegative regulation of mast cell activationQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechnegative regulation of mast cell degranulationQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechpost-embryonic root developmentQ9LT31
Vacuolar protein sorting-associated protein 9A
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechregulation of Fc receptor mediated stimulatory signaling pathwayQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechRABX5, catalytic core helical domainQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechRABX5, catalytic core helical domainQ9LT31
Vacuolar protein sorting-associated protein 9A
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechRABX5, catalytic core helical domainQ9UJ41
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechRABX5, catalytic core helical domain
trait identifier
DUF5601 (PF18151)ProteinTraitsMechVPS9 domainQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechVPS9 domainQ9LT31
Vacuolar protein sorting-associated protein 9A
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechZinc finger, A20-typeQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechZinc finger, A20-typeQ9UJ41
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechDomain of unknown function (DUF5601)O18973
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechDomain of unknown function (DUF5601)Q14C86
GTPase-activating protein and VPS9 domain-containing protein 1
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechDomain of unknown function (DUF5601)Q9UJ41
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechDomain of unknown function (DUF5601)
trait identifier
DUF5601 (PF18151)ProteinTraitsMechA20-like zinc fingerQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechA20-like zinc fingerQ9UJ41
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechVacuolar sorting protein 9 (VPS9) domainQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechVacuolar sorting protein 9 (VPS9) domainQ9LT31
Vacuolar protein sorting-associated protein 9A
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechVPS9 domain superfamilyQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechVPS9 domain superfamilyQ9LT31
Vacuolar protein sorting-associated protein 9A
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechVPS9 domain profileQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechVPS9 domain profileQ9LT31
Vacuolar protein sorting-associated protein 9A
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechZinc finger A20-type profileQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechZinc finger A20-type profileQ9UJ41
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechCATH homologous superfamily 1.10.246.120Q9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechCATH homologous superfamily 1.10.246.120Q9LT31
Vacuolar protein sorting-associated protein 9A
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechCATH homologous superfamily 1.10.246.120Q9UJ41
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechCATH homologous superfamily 1.20.5.4770Q9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechCATH homologous superfamily 1.20.5.4770Q9UJ41
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechVPS9 domainQ9JM13
Rab5 GDP/GTP exchange factor
canonical example family classification
DUF5601 (PF18151)ProteinTraitsMechVPS9 domainQ9LT31
Vacuolar protein sorting-associated protein 9A
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF18151.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.