All families / PF18151
PF18151: DUF5601
Domain of unknown function (DUF5601)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF18151: Domain of unknown function (DUF5601)
IPR041545: integrated entry for Domain of unknown function (DUF5601)
Source description
This domain is found in the catalytic core RABEX-5 present in Homo sapiens. RABEX, also known as Rab GTPase exchange factors, regulate endocytic trafficking through activation of the Rab families RAB5, RAB21 and RAB22. The domain is helical in nature [InterPro reference PUB00042275].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
6 verified sequence examples. FASTA
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 6,756
- matches
- 6,758
- proteomes
- 3,165
- taxa
- 8,367
- structures
- 9
- alphafold models
- 4,099
- domain architectures
- 99
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF5601 (PF18151) | ProteinTraitsMech | cell plate assembly | Q9LT31 Vacuolar protein sorting-associated protein 9A | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | cell wall biogenesis | Q9LT31 Vacuolar protein sorting-associated protein 9A | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | dendritic transport | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | dendritic transport | Q9UJ41 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | negative regulation of Kit signaling pathway | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | negative regulation of mast cell activation | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | negative regulation of mast cell degranulation | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | post-embryonic root development | Q9LT31 Vacuolar protein sorting-associated protein 9A | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | regulation of Fc receptor mediated stimulatory signaling pathway | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | RABX5, catalytic core helical domain | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | RABX5, catalytic core helical domain | Q9LT31 Vacuolar protein sorting-associated protein 9A | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | RABX5, catalytic core helical domain | Q9UJ41 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | RABX5, catalytic core helical domain | trait identifier | |
| DUF5601 (PF18151) | ProteinTraitsMech | VPS9 domain | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | VPS9 domain | Q9LT31 Vacuolar protein sorting-associated protein 9A | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | Zinc finger, A20-type | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | Zinc finger, A20-type | Q9UJ41 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | Domain of unknown function (DUF5601) | O18973 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | Domain of unknown function (DUF5601) | Q14C86 GTPase-activating protein and VPS9 domain-containing protein 1 | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | Domain of unknown function (DUF5601) | Q9UJ41 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | Domain of unknown function (DUF5601) | trait identifier | |
| DUF5601 (PF18151) | ProteinTraitsMech | A20-like zinc finger | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | A20-like zinc finger | Q9UJ41 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | Vacuolar sorting protein 9 (VPS9) domain | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | Vacuolar sorting protein 9 (VPS9) domain | Q9LT31 Vacuolar protein sorting-associated protein 9A | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | VPS9 domain superfamily | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | VPS9 domain superfamily | Q9LT31 Vacuolar protein sorting-associated protein 9A | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | VPS9 domain profile | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | VPS9 domain profile | Q9LT31 Vacuolar protein sorting-associated protein 9A | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | Zinc finger A20-type profile | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | Zinc finger A20-type profile | Q9UJ41 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | CATH homologous superfamily 1.10.246.120 | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | CATH homologous superfamily 1.10.246.120 | Q9LT31 Vacuolar protein sorting-associated protein 9A | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | CATH homologous superfamily 1.10.246.120 | Q9UJ41 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | CATH homologous superfamily 1.20.5.4770 | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | CATH homologous superfamily 1.20.5.4770 | Q9UJ41 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | VPS9 domain | Q9JM13 Rab5 GDP/GTP exchange factor | canonical example family classification |
| DUF5601 (PF18151) | ProteinTraitsMech | VPS9 domain | Q9LT31 Vacuolar protein sorting-associated protein 9A | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.