DUFMech

All families / PF18474

PF18474: DUF5614

Family of unknown function (DUF5614)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF18474: Family of unknown function (DUF5614)
IPR041076: integrated entry for Family of unknown function (DUF5614)

Source description

This is an N-terminal domain found in C7orf25 protein UPF0415. It is distantly related to the PD-(D/E)XK nucleases [InterPro reference PUB00091006].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

5 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
Q1LZE8UPF0415 protein C7orf25 homolog
Bos taurus		421 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q5M888UPF0415 protein C7orf25 homolog
Rattus norvegicus		421 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q803H0UPF0415 protein C7orf25 homolog
Danio rerio		427 aa; version 1
UniProt 2026_03		UNIPROT FETCH
1 sibling references
Q91WD4UPF0415 protein C7orf25 homolog
Mus musculus		421 aa; version 1
UniProt 2026_03		UNIPROT FETCH
2 sibling references
Q9BPX7UPF0415 protein C7orf25
Homo sapiens		421 aa; version 1
UniProt 2026_03		UNIPROT FETCH
4 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
1,368
matches
1,375
proteomes
1,160
taxa
3,892
structures
0
alphafold models
1,226
domain architectures
27

Classification basis

short name matches duf; name says unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF5614 (PF18474)ProteinTraitsMechDomain of unknown function DUF1308Q91WD4
UPF0415 protein C7orf25 homolog		canonical example family classification
DUF5614 (PF18474)ProteinTraitsMechDomain of unknown function DUF1308Q9BPX7
UPF0415 protein C7orf25		canonical example family classification
DUF5614 (PF18474)ProteinTraitsMechDomain of unknown function DUF5614Q91WD4
UPF0415 protein C7orf25 homolog		canonical example family classification
DUF5614 (PF18474)ProteinTraitsMechDomain of unknown function DUF5614Q9BPX7
UPF0415 protein C7orf25		canonical example family classification
DUF5614 (PF18474)ProteinTraitsMechDomain of unknown function DUF5614
trait identifier
DUF5614 (PF18474)ProteinTraitsMechProtein of unknown function (DUF1308)Q1LZE8
UPF0415 protein C7orf25 homolog		canonical example family classification
DUF5614 (PF18474)ProteinTraitsMechProtein of unknown function (DUF1308)Q5M888
UPF0415 protein C7orf25 homolog		canonical example family classification
DUF5614 (PF18474)ProteinTraitsMechProtein of unknown function (DUF1308)Q9BPX7
UPF0415 protein C7orf25		canonical example family classification
DUF5614 (PF18474)ProteinTraitsMechFamily of unknown function (DUF5614)Q1LZE8
UPF0415 protein C7orf25 homolog		canonical example family classification
DUF5614 (PF18474)ProteinTraitsMechFamily of unknown function (DUF5614)Q803H0
UPF0415 protein C7orf25 homolog		canonical example family classification
DUF5614 (PF18474)ProteinTraitsMechFamily of unknown function (DUF5614)Q9BPX7
UPF0415 protein C7orf25		canonical example family classification
DUF5614 (PF18474)ProteinTraitsMechFamily of unknown function (DUF5614)
trait identifier

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF18474.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.