All families / PF19213
PF19213: CoV_NSP6
Coronavirus replicase NSP6
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF19213: Coronavirus replicase NSP6
IPR043610: integrated entry for Coronavirus replicase NSP6
Source description
This entry represents proteins found in Coronaviruses and includes the Non-structural Protein 6 (NSP6). Coronaviruses encode large replicase polyproteins which are proteolytically processed by viral proteases to generate mature Nonstructural Proteins (NSPs) [InterPro reference PUB00094417]. NSP6 is a membrane protein containing 6 transmembrane domains with a large C-terminal tail [InterPro reference PUB00094417]. NSP6 from the avian coronavirus, infectious bronchitis virus (IBV) and the mouse hepatitis virus (MHV) have been shown to localise to the ER and to generate autophagosomes [InterPro reference PUB00094416]. Coronavirus NSP6 proteins have also been shown to limit autophagosome expansion. This may favour coronavirus infection by reducing the ability of autophagosomes to deliver viral components to lysosomes for degradation [InterPro reference PUB00094416]. NSP6 from IBV, MHV and severe acute respiratory syndrome coronavirus (SARS-CoV) have also been found to activate autophagy [InterPro reference PUB00094416,InterPro reference PUB00094418].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
22 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| K9N7C7 | Replicase polyprotein 1ab Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) | 7078 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P0C6F5 | Replicase polyprotein 1a Bat coronavirus 279/2005 | 4388 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| P0C6F6 | Replicase polyprotein 1a Bat coronavirus 512/2005 | 4128 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| P0C6F7 | Replicase polyprotein 1a Bat coronavirus 133/2005 | 4441 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P0C6F8 | Replicase polyprotein 1a Bat coronavirus HKU3 | 4376 aa; version 1 UniProt 2026_03 | UNIPROT FETCH11 sibling references
|
| P0C6T8 | Replicase polyprotein 1a Bovine coronavirus (strain 98TXSF-110-ENT) | 4383 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P0C6T9 | Replicase polyprotein 1a Bovine coronavirus (strain 98TXSF-110-LUN) | 4383 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P0C6U4 | Replicase polyprotein 1a Human coronavirus HKU1 (isolate N2) | 4441 aa; version 1 UniProt 2026_03 | UNIPROT FETCH10 sibling references
|
| P0C6U6 | Replicase polyprotein 1a Human coronavirus NL63 | 4060 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P0C6U7 | Replicase polyprotein 1a Human coronavirus OC43 | 4383 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
First 10 shown; the FASTA and family JSON contain all examples.
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 1,387
- matches
- 1,387
- proteomes
- 59
- taxa
- 328
- structures
- 0
- alphafold models
- 81
- domain architectures
- 81
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.