All families / PF19314
PF19314: DUF5917
Family of unknown function (DUF5917)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF19314: Family of unknown function (DUF5917)
IPR045669: integrated entry for Family of unknown function (DUF5917)
Source description
This short presumed domain is found close to the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
9 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q05DH4 | FHF complex subunit HOOK-interacting protein 1A Homo sapiens | 1040 aa; version 2 UniProt 2026_03 | PTM REGISTRY MIRROR |
| Q11187 | FHIP family protein C05D11.8 Caenorhabditis elegans | 920 aa; version 3 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q3U2I3 | FHF complex subunit HOOK-interacting protein 1B Mus musculus | 975 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q505K2 | FHF complex subunit HOOK-interacting protein 1A Mus musculus | 1081 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q5W0V3 | FHF complex subunit HOOK interacting protein 2A Homo sapiens | 765 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q80YR2 | FHF complex subunit HOOK-interacting protein 2B Mus musculus | 744 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q86V87 | FHF complex subunit HOOK-interacting protein 2B Homo sapiens | 743 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q8CDM8 | FHF complex subunit HOOK interacting protein 2A Mus musculus | 764 aa; version 2 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q8N612 | FHF complex subunit HOOK-interacting protein 1B Homo sapiens | 972 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 5,822
- matches
- 5,825
- proteomes
- 2,033
- taxa
- 5,875
- structures
- 1
- alphafold models
- 4,957
- domain architectures
- 73
Classification basis
short name matches duf; name says unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, KELAA motif | Q05DH4 FHF complex subunit HOOK-interacting protein 1A | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, KELAA motif | Q3U2I3 FHF complex subunit HOOK-interacting protein 1B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, KELAA motif | Q505K2 FHF complex subunit HOOK-interacting protein 1A | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, KELAA motif | Q5W0V3 FHF complex subunit HOOK interacting protein 2A | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, KELAA motif | Q80YR2 FHF complex subunit HOOK-interacting protein 2B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, KELAA motif | Q86V87 FHF complex subunit HOOK-interacting protein 2B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, KELAA motif | Q8CDM8 FHF complex subunit HOOK interacting protein 2A | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, KELAA motif | Q8N612 FHF complex subunit HOOK-interacting protein 1B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, C-terminal | Q05DH4 FHF complex subunit HOOK-interacting protein 1A | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, C-terminal | Q11187 FHIP family protein C05D11.8 | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, C-terminal | Q3U2I3 FHF complex subunit HOOK-interacting protein 1B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, C-terminal | Q505K2 FHF complex subunit HOOK-interacting protein 1A | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, C-terminal | Q5W0V3 FHF complex subunit HOOK interacting protein 2A | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, C-terminal | Q80YR2 FHF complex subunit HOOK-interacting protein 2B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, C-terminal | Q8CDM8 FHF complex subunit HOOK interacting protein 2A | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, C-terminal | Q8N612 FHF complex subunit HOOK-interacting protein 1B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | FHF complex subunit HOOK-interacting protein, C-terminal | trait identifier | |
| DUF5917 (PF19314) | ProteinTraitsMech | Family of unknown function (DUF5917) | Q05DH4 FHF complex subunit HOOK-interacting protein 1A | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | Family of unknown function (DUF5917) | Q3U2I3 FHF complex subunit HOOK-interacting protein 1B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | Family of unknown function (DUF5917) | Q8N612 FHF complex subunit HOOK-interacting protein 1B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | Family of unknown function (DUF5917) | trait identifier | |
| DUF5917 (PF19314) | ProteinTraitsMech | KELAA motif | Q3U2I3 FHF complex subunit HOOK-interacting protein 1B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | KELAA motif | Q86V87 FHF complex subunit HOOK-interacting protein 2B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | KELAA motif | Q8N612 FHF complex subunit HOOK-interacting protein 1B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | Retinoic acid induced 16-like protein | Q05DH4 FHF complex subunit HOOK-interacting protein 1A | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | Retinoic acid induced 16-like protein | Q3U2I3 FHF complex subunit HOOK-interacting protein 1B | canonical example family classification |
| DUF5917 (PF19314) | ProteinTraitsMech | Retinoic acid induced 16-like protein | Q8N612 FHF complex subunit HOOK-interacting protein 1B | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.